K-ras mutation in sputum of primary lung cancer patients does not always reflect that of cancerous cells.

  • Authors:
    • E Nakajima
    • T Hirano
    • C Konaka
    • N Ikeda
    • N Kawate
    • Y Ebihara
    • H Kato
  • View Affiliations

  • Published online on: January 1, 2001     https://doi.org/10.3892/ijo.18.1.105
  • Pages: 105-115
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Abstract

K-ras mutation in sputum was examined using mutant-allele-specific amplification method among 100 primary lung cancer and 15 non-oncological patients. K-ras mutation was detected in 11 out of 59 adenocarcinoma cases (18.6%), 5 out of 32 squamous cell carcinoma cases (15.6%), 2 out of 4 large cell carcinoma cases (50.0%) and 3 out of 15 non-oncological disease cases (20.0%). In the 18 cases of primary lung cancer K-ras mutation was examined in both sputum and the resected specimen of the primary lesion. In 5 cases K-ras mutation in sputum was detected without K-ras mutation in primary lesion. Therefore, these findings suggested that K-ras mutation in sputum may not be directly related to that of the primary lesion.

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January 2001
Volume 18 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Nakajima E, Hirano T, Konaka C, Ikeda N, Kawate N, Ebihara Y and Kato H: K-ras mutation in sputum of primary lung cancer patients does not always reflect that of cancerous cells.. Int J Oncol 18: 105-115, 2001
APA
Nakajima, E., Hirano, T., Konaka, C., Ikeda, N., Kawate, N., Ebihara, Y., & Kato, H. (2001). K-ras mutation in sputum of primary lung cancer patients does not always reflect that of cancerous cells.. International Journal of Oncology, 18, 105-115. https://doi.org/10.3892/ijo.18.1.105
MLA
Nakajima, E., Hirano, T., Konaka, C., Ikeda, N., Kawate, N., Ebihara, Y., Kato, H."K-ras mutation in sputum of primary lung cancer patients does not always reflect that of cancerous cells.". International Journal of Oncology 18.1 (2001): 105-115.
Chicago
Nakajima, E., Hirano, T., Konaka, C., Ikeda, N., Kawate, N., Ebihara, Y., Kato, H."K-ras mutation in sputum of primary lung cancer patients does not always reflect that of cancerous cells.". International Journal of Oncology 18, no. 1 (2001): 105-115. https://doi.org/10.3892/ijo.18.1.105