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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2001 Volume 18 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2001 Volume 18 Issue 2

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Article

Tree models for dependent copy number changes in bladder cancer

  • Authors:
    • Alejandro A. Schaffer
    • Ronald Simon
    • Richard Desper
    • Jan Richter
    • Guido Sauter

  • View Affiliations / Copyright

    Affiliations: NCBI/NIH, Bldg 38A, Room 8N805, Bethesda, MD 20894, USA
  • Pages: 349-354
    |
    Published online on: February 1, 2001
       https://doi.org/10.3892/ijo.18.2.349
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Abstract

We analyzed comparative genomic hybridization data on a collection of 237 bladder cancer tumors with the aim of identifying sets of copy number aberrations (CNAs) that tend to occur together. A test based on Fisher's exact test for pairs, but taking into account multiple testing, showed strong dependencies amongst several pairs of aberrations including (+1q, -11p), (+17q, +20q), (+10p, -17p), (-8p, -17p), (+5p, +10p). To determine whether co-occurrence of CNAs may characterize tumor subtypes, we used two recently proposed methods to construct tree models of tumor progression. We constructed tree models for all the tumors, the tumors of stage pT1, and the tumors of stages pT2-4. The tree models confirmed that most of the non-random events and the associations are the same for different stages. We conclude that the combination of large data sets and tree models provide a useful approach to systematically identifying tumor subgroups characterized by more than a single chromosomal aberration.

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Copy and paste a formatted citation
Spandidos Publications style
Schaffer AA, Simon R, Desper R, Richter J and Sauter G: Tree models for dependent copy number changes in bladder cancer. Int J Oncol 18: 349-354, 2001.
APA
Schaffer, A.A., Simon, R., Desper, R., Richter, J., & Sauter, G. (2001). Tree models for dependent copy number changes in bladder cancer. International Journal of Oncology, 18, 349-354. https://doi.org/10.3892/ijo.18.2.349
MLA
Schaffer, A. A., Simon, R., Desper, R., Richter, J., Sauter, G."Tree models for dependent copy number changes in bladder cancer". International Journal of Oncology 18.2 (2001): 349-354.
Chicago
Schaffer, A. A., Simon, R., Desper, R., Richter, J., Sauter, G."Tree models for dependent copy number changes in bladder cancer". International Journal of Oncology 18, no. 2 (2001): 349-354. https://doi.org/10.3892/ijo.18.2.349
Copy and paste a formatted citation
x
Spandidos Publications style
Schaffer AA, Simon R, Desper R, Richter J and Sauter G: Tree models for dependent copy number changes in bladder cancer. Int J Oncol 18: 349-354, 2001.
APA
Schaffer, A.A., Simon, R., Desper, R., Richter, J., & Sauter, G. (2001). Tree models for dependent copy number changes in bladder cancer. International Journal of Oncology, 18, 349-354. https://doi.org/10.3892/ijo.18.2.349
MLA
Schaffer, A. A., Simon, R., Desper, R., Richter, J., Sauter, G."Tree models for dependent copy number changes in bladder cancer". International Journal of Oncology 18.2 (2001): 349-354.
Chicago
Schaffer, A. A., Simon, R., Desper, R., Richter, J., Sauter, G."Tree models for dependent copy number changes in bladder cancer". International Journal of Oncology 18, no. 2 (2001): 349-354. https://doi.org/10.3892/ijo.18.2.349
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