Comparative study of angiostatic and anti-invasive gene expressions as prognostic factors in gastric cancer

  • Authors:
    • J. H. Lee
    • J. T. Koh
    • B. A. Shin
    • K. Y. Ahn
    • J. H. Roh
    • Y. J. Kim
    • K. K. Kim
  • View Affiliations

  • Published online on: February 1, 2001     https://doi.org/10.3892/ijo.18.2.355
  • Pages: 355-361
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Genes involving angiogenesis and metastasis play an important role in the progression and infiltration of cancer. We examined the expressions of various angiostatic and potential invasion/metastasis suppressor genes through RT-PCR analyses in 32 gastric cancer specimens with or without distant metastasis. The expressions of the invasion/metastasis suppressor, nm23 and E-cadherin increased much more in the cancer tissue (CT) and metastatic lymph node (MLN) than in the extraneoplastic mucosa (EM) and non-metastatic lymph node (NLN), respectively. The expressions of the angiostatic factor, angiopoietin 2 and thrombospondin 2 increased in the CT and MLN as compared with the EM and NLN, respectively. The newly cloned angiostatic factor, brain-specific angiogenesis inhibitor 1 (BAI1) decreased much more in the CT and MLN than the EM and NLN, respectively. However, BAI1 increased in the CT compared with the EM among the patients with poor prognosis and distant metastasis, such as liver or peritoneum. The expressions of the invasive factor, matrix metalloproteinase-2 and its suppressor, tissue inhibitor metalloproteinase-2 (TIMP-2) increased in the CM as compared with the EM, but the increased expression pattern of these genes in the CT became blunted among the patients with good prognosis. Our results indicate that BAI1 and TIMP-2 expressions in the extraneoplastic mucosa and non-metastatic lymph nodes were not suppressed in the patients with good prognosis, but increased expressions of angiopoietin 2, thrombospondin 2, TIMP-2, nm23 and E-cadherin in the tumor tissue did not lead to a long survival after operation. It is suggested that the extent of BAI1 and TIMP-2 expression in the gastric mucosa may be an important prognostic factor for predicting survival in gastric cancer.

Related Articles

Journal Cover

February 2001
Volume 18 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Lee JH, Koh JT, Shin BA, Ahn KY, Roh JH, Kim YJ and Kim KK: Comparative study of angiostatic and anti-invasive gene expressions as prognostic factors in gastric cancer. Int J Oncol 18: 355-361, 2001.
APA
Lee, J.H., Koh, J.T., Shin, B.A., Ahn, K.Y., Roh, J.H., Kim, Y.J., & Kim, K.K. (2001). Comparative study of angiostatic and anti-invasive gene expressions as prognostic factors in gastric cancer. International Journal of Oncology, 18, 355-361. https://doi.org/10.3892/ijo.18.2.355
MLA
Lee, J. H., Koh, J. T., Shin, B. A., Ahn, K. Y., Roh, J. H., Kim, Y. J., Kim, K. K."Comparative study of angiostatic and anti-invasive gene expressions as prognostic factors in gastric cancer". International Journal of Oncology 18.2 (2001): 355-361.
Chicago
Lee, J. H., Koh, J. T., Shin, B. A., Ahn, K. Y., Roh, J. H., Kim, Y. J., Kim, K. K."Comparative study of angiostatic and anti-invasive gene expressions as prognostic factors in gastric cancer". International Journal of Oncology 18, no. 2 (2001): 355-361. https://doi.org/10.3892/ijo.18.2.355