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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 2001 Volume 18 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2001 Volume 18 Issue 3

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Article

Intravenous readministration of an adenoviral vector performed long after the initial administration failed to induce re-expression of the original transgene in rats

  • Authors:
    • H. Tsujinoue
    • S. Kuriyama
    • K. Tominaga
    • H. Okuda
    • T. Nakatani
    • H. Yoshiji
    • T. Tsujimoto
    • T. Akahane
    • K. Asada
    • H. Fukui
  • View Affiliations / Copyright

    Affiliations: Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara 634-8522, Japan
  • Pages: 575-580
    |
    Published online on: March 1, 2001
       https://doi.org/10.3892/ijo.18.3.575
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Abstract

Although most humans have been exposed to wild-type adenoviruses in their childhood, titers of neutralizing antibodies against viruses decrease with the passage of time. In the present study, we infused adenoviruses carrying the lacZ gene into the tail vein of rats, and re-infused the same adenoviruses long after the initial administration. However, development of neutralizing antibodies against adenovirus and proliferation of adenovirus-specific T cells were elicited profoundly by adenoviral readministration, and transgene expression was not induced in rats. Our results may have important implications for efficacy considerations when adenoviral vectors are employed in clinical settings for the treatment of cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Tsujinoue H, Kuriyama S, Tominaga K, Okuda H, Nakatani T, Yoshiji H, Tsujimoto T, Akahane T, Asada K, Fukui H, Fukui H, et al: Intravenous readministration of an adenoviral vector performed long after the initial administration failed to induce re-expression of the original transgene in rats. Int J Oncol 18: 575-580, 2001.
APA
Tsujinoue, H., Kuriyama, S., Tominaga, K., Okuda, H., Nakatani, T., Yoshiji, H. ... Fukui, H. (2001). Intravenous readministration of an adenoviral vector performed long after the initial administration failed to induce re-expression of the original transgene in rats. International Journal of Oncology, 18, 575-580. https://doi.org/10.3892/ijo.18.3.575
MLA
Tsujinoue, H., Kuriyama, S., Tominaga, K., Okuda, H., Nakatani, T., Yoshiji, H., Tsujimoto, T., Akahane, T., Asada, K., Fukui, H."Intravenous readministration of an adenoviral vector performed long after the initial administration failed to induce re-expression of the original transgene in rats". International Journal of Oncology 18.3 (2001): 575-580.
Chicago
Tsujinoue, H., Kuriyama, S., Tominaga, K., Okuda, H., Nakatani, T., Yoshiji, H., Tsujimoto, T., Akahane, T., Asada, K., Fukui, H."Intravenous readministration of an adenoviral vector performed long after the initial administration failed to induce re-expression of the original transgene in rats". International Journal of Oncology 18, no. 3 (2001): 575-580. https://doi.org/10.3892/ijo.18.3.575
Copy and paste a formatted citation
x
Spandidos Publications style
Tsujinoue H, Kuriyama S, Tominaga K, Okuda H, Nakatani T, Yoshiji H, Tsujimoto T, Akahane T, Asada K, Fukui H, Fukui H, et al: Intravenous readministration of an adenoviral vector performed long after the initial administration failed to induce re-expression of the original transgene in rats. Int J Oncol 18: 575-580, 2001.
APA
Tsujinoue, H., Kuriyama, S., Tominaga, K., Okuda, H., Nakatani, T., Yoshiji, H. ... Fukui, H. (2001). Intravenous readministration of an adenoviral vector performed long after the initial administration failed to induce re-expression of the original transgene in rats. International Journal of Oncology, 18, 575-580. https://doi.org/10.3892/ijo.18.3.575
MLA
Tsujinoue, H., Kuriyama, S., Tominaga, K., Okuda, H., Nakatani, T., Yoshiji, H., Tsujimoto, T., Akahane, T., Asada, K., Fukui, H."Intravenous readministration of an adenoviral vector performed long after the initial administration failed to induce re-expression of the original transgene in rats". International Journal of Oncology 18.3 (2001): 575-580.
Chicago
Tsujinoue, H., Kuriyama, S., Tominaga, K., Okuda, H., Nakatani, T., Yoshiji, H., Tsujimoto, T., Akahane, T., Asada, K., Fukui, H."Intravenous readministration of an adenoviral vector performed long after the initial administration failed to induce re-expression of the original transgene in rats". International Journal of Oncology 18, no. 3 (2001): 575-580. https://doi.org/10.3892/ijo.18.3.575
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