The clavicle: A vulnerable bone in pediatric oncology

  • Authors:
    • Hallie Zietz
    • Su Berrak
    • Hubert Ried
    • Kristin Weber
    • Moshe Maor
    • Norman Jaffe
  • View Affiliations

  • Published online on: April 1, 2001     https://doi.org/10.3892/ijo.18.4.689
  • Pages: 689-695
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Abstract

The clavicle is frequently incorporated into the radiation field in the treatment of malignant tumors located in the head and neck. From 1954 to 1995, 499 pediatric patients were treated with moderate to high-dose radiation therapy to the head and neck at the University of Texas M.D. Anderson Cancer Center. The medical records of 312 of these patients were available and were reviewed. The period of observation ranged from 5 to 30 years. Five late radiation-induced abnormalities of the clavicle were encountered: osteosarcoma; osteochondroma; malignant fibrous histiocytoma; radionecrosis and impaired healing following trauma and radionecrosis and lysis. The doses of radiation therapy which induced the abnormalities varied from 35 to 60.5 Gy (median 34.75 Gy). The interval from radiation therapy to discovery of the complications varied from 6 to 11 years. Two patients died: one from malignant fibrous histiocytoma and another from a radiation-induced meningioma of the brain (which accompanied radionecrosis of the clavicle). We conclude that the incidence of radiation-induced abnormalities of the clavicle in pediatric long-term survivors is low (1.5%). However, some of the late sequela are potentially fatal. The clavicle should be considered a vulnerable bone to radiation therapy and should be monitored in long-term survivors of childhood cancer. The experience is compared to radiation-induced abnormalities recorded in the literature.

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April 2001
Volume 18 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Zietz H, Berrak S, Ried H, Weber K, Maor M and Jaffe N: The clavicle: A vulnerable bone in pediatric oncology. Int J Oncol 18: 689-695, 2001
APA
Zietz, H., Berrak, S., Ried, H., Weber, K., Maor, M., & Jaffe, N. (2001). The clavicle: A vulnerable bone in pediatric oncology. International Journal of Oncology, 18, 689-695. https://doi.org/10.3892/ijo.18.4.689
MLA
Zietz, H., Berrak, S., Ried, H., Weber, K., Maor, M., Jaffe, N."The clavicle: A vulnerable bone in pediatric oncology". International Journal of Oncology 18.4 (2001): 689-695.
Chicago
Zietz, H., Berrak, S., Ried, H., Weber, K., Maor, M., Jaffe, N."The clavicle: A vulnerable bone in pediatric oncology". International Journal of Oncology 18, no. 4 (2001): 689-695. https://doi.org/10.3892/ijo.18.4.689