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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2001 Volume 18 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2001 Volume 18 Issue 4

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Article

Galectin-3 maintains the transformed phenotype of thyroid papillary carcinoma cells

  • Authors:
    • T. Yoshii
    • H. Inohara
    • Y. Takenaka
    • Y. Honjo
    • S. Akahani
    • T. Nomura
    • A. Raz
    • T. Kubo

  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology and Sensory Organ Surgery, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan
  • Pages: 787-792
    |
    Published online on: April 1, 2001
       https://doi.org/10.3892/ijo.18.4.787
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Abstract

Galectin-3, a β-galactoside-binding protein, is highly expressed in thyroid papillary carcinomas, while functional relevance of galectin-3 overexpression to the malignant phenotype remains elusive. In the present study we transfected galectin-3 antisense cDNA into the human thyroid papillary carcinoma cell line NPA which expresses an innately high level of galectin-3, and examined the effect of antisense inhibition of galectin-3 expression on the transformed phenotype. There was no difference in anchorage-dependent growth between the antisense clones and either the control or parental clones. In contrast, anchorage-independent growth and saturation density of the antisense clones were significantly suppressed compared to those of either the control or parental clones. These results demonstrate that overexpression of galectin-3 in thyroid papillary carcinoma cells is necessary for the maintenance of transformed phenotype, and suggest galectin-3 as a potential target for therapeutic interventions in the future.

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Copy and paste a formatted citation
Spandidos Publications style
Yoshii T, Inohara H, Takenaka Y, Honjo Y, Akahani S, Nomura T, Raz A and Kubo T: Galectin-3 maintains the transformed phenotype of thyroid papillary carcinoma cells. Int J Oncol 18: 787-792, 2001.
APA
Yoshii, T., Inohara, H., Takenaka, Y., Honjo, Y., Akahani, S., Nomura, T. ... Kubo, T. (2001). Galectin-3 maintains the transformed phenotype of thyroid papillary carcinoma cells. International Journal of Oncology, 18, 787-792. https://doi.org/10.3892/ijo.18.4.787
MLA
Yoshii, T., Inohara, H., Takenaka, Y., Honjo, Y., Akahani, S., Nomura, T., Raz, A., Kubo, T."Galectin-3 maintains the transformed phenotype of thyroid papillary carcinoma cells". International Journal of Oncology 18.4 (2001): 787-792.
Chicago
Yoshii, T., Inohara, H., Takenaka, Y., Honjo, Y., Akahani, S., Nomura, T., Raz, A., Kubo, T."Galectin-3 maintains the transformed phenotype of thyroid papillary carcinoma cells". International Journal of Oncology 18, no. 4 (2001): 787-792. https://doi.org/10.3892/ijo.18.4.787
Copy and paste a formatted citation
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Spandidos Publications style
Yoshii T, Inohara H, Takenaka Y, Honjo Y, Akahani S, Nomura T, Raz A and Kubo T: Galectin-3 maintains the transformed phenotype of thyroid papillary carcinoma cells. Int J Oncol 18: 787-792, 2001.
APA
Yoshii, T., Inohara, H., Takenaka, Y., Honjo, Y., Akahani, S., Nomura, T. ... Kubo, T. (2001). Galectin-3 maintains the transformed phenotype of thyroid papillary carcinoma cells. International Journal of Oncology, 18, 787-792. https://doi.org/10.3892/ijo.18.4.787
MLA
Yoshii, T., Inohara, H., Takenaka, Y., Honjo, Y., Akahani, S., Nomura, T., Raz, A., Kubo, T."Galectin-3 maintains the transformed phenotype of thyroid papillary carcinoma cells". International Journal of Oncology 18.4 (2001): 787-792.
Chicago
Yoshii, T., Inohara, H., Takenaka, Y., Honjo, Y., Akahani, S., Nomura, T., Raz, A., Kubo, T."Galectin-3 maintains the transformed phenotype of thyroid papillary carcinoma cells". International Journal of Oncology 18, no. 4 (2001): 787-792. https://doi.org/10.3892/ijo.18.4.787
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