Galectin-3 maintains the transformed phenotype of thyroid papillary carcinoma cells

  • Authors:
    • T. Yoshii
    • H. Inohara
    • Y. Takenaka
    • Y. Honjo
    • S. Akahani
    • T. Nomura
    • A. Raz
    • T. Kubo
  • View Affiliations

  • Published online on: April 1, 2001     https://doi.org/10.3892/ijo.18.4.787
  • Pages: 787-792
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Abstract

Galectin-3, a β-galactoside-binding protein, is highly expressed in thyroid papillary carcinomas, while functional relevance of galectin-3 overexpression to the malignant phenotype remains elusive. In the present study we transfected galectin-3 antisense cDNA into the human thyroid papillary carcinoma cell line NPA which expresses an innately high level of galectin-3, and examined the effect of antisense inhibition of galectin-3 expression on the transformed phenotype. There was no difference in anchorage-dependent growth between the antisense clones and either the control or parental clones. In contrast, anchorage-independent growth and saturation density of the antisense clones were significantly suppressed compared to those of either the control or parental clones. These results demonstrate that overexpression of galectin-3 in thyroid papillary carcinoma cells is necessary for the maintenance of transformed phenotype, and suggest galectin-3 as a potential target for therapeutic interventions in the future.

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April 2001
Volume 18 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Yoshii T, Inohara H, Takenaka Y, Honjo Y, Akahani S, Nomura T, Raz A and Kubo T: Galectin-3 maintains the transformed phenotype of thyroid papillary carcinoma cells. Int J Oncol 18: 787-792, 2001.
APA
Yoshii, T., Inohara, H., Takenaka, Y., Honjo, Y., Akahani, S., Nomura, T. ... Kubo, T. (2001). Galectin-3 maintains the transformed phenotype of thyroid papillary carcinoma cells. International Journal of Oncology, 18, 787-792. https://doi.org/10.3892/ijo.18.4.787
MLA
Yoshii, T., Inohara, H., Takenaka, Y., Honjo, Y., Akahani, S., Nomura, T., Raz, A., Kubo, T."Galectin-3 maintains the transformed phenotype of thyroid papillary carcinoma cells". International Journal of Oncology 18.4 (2001): 787-792.
Chicago
Yoshii, T., Inohara, H., Takenaka, Y., Honjo, Y., Akahani, S., Nomura, T., Raz, A., Kubo, T."Galectin-3 maintains the transformed phenotype of thyroid papillary carcinoma cells". International Journal of Oncology 18, no. 4 (2001): 787-792. https://doi.org/10.3892/ijo.18.4.787