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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2001 Volume 18 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2001 Volume 18 Issue 4

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Article

RPR-115135, a new non peptidomimetic farnesyltransferase inhibitor, induces G0/G1 arrest only in serum starved cells

  • Authors:
    • Patrizia Russo
    • Cristina Ottoboni
    • Alessandra Crippa
    • Jean-Francois Riou
    • Patrick M. O'Connor

  • View Affiliations / Copyright

    Affiliations: Molecular Pathology Section, Laboratory of Experimental Oncology, National Cancer Research Institute, I-16132 Genova, Italy
  • Pages: 855-862
    |
    Published online on: April 1, 2001
       https://doi.org/10.3892/ijo.18.4.855
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Abstract

A new non peptidomimetic farnesyltransferase inhibitor, RPR-115135, was studied in an isogenic cell model system consisting of human colon cancer HCT-116 line. HCT-116 cells were transfected with an empty control pCMV vector or with a dominant-negative mutated p53 transgene to disrupt p53 function. Growth inhibitory effects of RPR-115135 were evaluated on cells growing under different conditions (serum starvation, serum starvation and recovery, nocodazole treatment). The cytotoxic activity of RPR-115135 was independent of the cell cycle status of the target cells. Addition of RPR-115135 only to cells exposed to reduced serum conditions (0.1% FCS) resulted in an enhanced ability of HCT-116 cells to arrest in the G0/G1 phase. This arrest response appeared independent of p53/p21cip1/waf-1 function. A reduction of Cyclin A protein amount by RPR-115135 was observed in both clones. These latter results suggest that RPR-115135 migth down-regulate the cell cycle factor that would normally impede G0/G1 arrest.

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Copy and paste a formatted citation
Spandidos Publications style
Russo P, Ottoboni C, Crippa A, Riou J and O'Connor PM: RPR-115135, a new non peptidomimetic farnesyltransferase inhibitor, induces G0/G1 arrest only in serum starved cells. Int J Oncol 18: 855-862, 2001.
APA
Russo, P., Ottoboni, C., Crippa, A., Riou, J., & O'Connor, P.M. (2001). RPR-115135, a new non peptidomimetic farnesyltransferase inhibitor, induces G0/G1 arrest only in serum starved cells. International Journal of Oncology, 18, 855-862. https://doi.org/10.3892/ijo.18.4.855
MLA
Russo, P., Ottoboni, C., Crippa, A., Riou, J., O'Connor, P. M."RPR-115135, a new non peptidomimetic farnesyltransferase inhibitor, induces G0/G1 arrest only in serum starved cells". International Journal of Oncology 18.4 (2001): 855-862.
Chicago
Russo, P., Ottoboni, C., Crippa, A., Riou, J., O'Connor, P. M."RPR-115135, a new non peptidomimetic farnesyltransferase inhibitor, induces G0/G1 arrest only in serum starved cells". International Journal of Oncology 18, no. 4 (2001): 855-862. https://doi.org/10.3892/ijo.18.4.855
Copy and paste a formatted citation
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Spandidos Publications style
Russo P, Ottoboni C, Crippa A, Riou J and O'Connor PM: RPR-115135, a new non peptidomimetic farnesyltransferase inhibitor, induces G0/G1 arrest only in serum starved cells. Int J Oncol 18: 855-862, 2001.
APA
Russo, P., Ottoboni, C., Crippa, A., Riou, J., & O'Connor, P.M. (2001). RPR-115135, a new non peptidomimetic farnesyltransferase inhibitor, induces G0/G1 arrest only in serum starved cells. International Journal of Oncology, 18, 855-862. https://doi.org/10.3892/ijo.18.4.855
MLA
Russo, P., Ottoboni, C., Crippa, A., Riou, J., O'Connor, P. M."RPR-115135, a new non peptidomimetic farnesyltransferase inhibitor, induces G0/G1 arrest only in serum starved cells". International Journal of Oncology 18.4 (2001): 855-862.
Chicago
Russo, P., Ottoboni, C., Crippa, A., Riou, J., O'Connor, P. M."RPR-115135, a new non peptidomimetic farnesyltransferase inhibitor, induces G0/G1 arrest only in serum starved cells". International Journal of Oncology 18, no. 4 (2001): 855-862. https://doi.org/10.3892/ijo.18.4.855
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