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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 2001 Volume 18 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2001 Volume 18 Issue 5

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Article

Polymorphism and allelic loss at the AS3 locus on 13q12-13 in esophageal squamous cell carcinoma

  • Authors:
    • Hideki Harada
    • Nobuhiro Uchida
    • Yutaka Shimada
    • Hiroshi Kumimoto
    • Masayuki Shinoda
    • Masayuki Imamura
    • Kanji Ishizaki

  • View Affiliations / Copyright

    Affiliations: Central Laboratory and Radiation Biology, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan
  • Pages: 1003-1007
    |
    Published online on: May 1, 2001
       https://doi.org/10.3892/ijo.18.5.1003
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Abstract

Our previous studies of esophageal squamous cell carcinoma (ESC) revealed that frequent loss of heterozygosity (LOH) on 13q12-13 was associated with lymph node metastasis. These results suggest that 13q12-13 may harbor a tumor suppressor gene which regulates lymph node metastasis. Recently, a new tumor suppressor candidate, AS3, was identified in this region. We therefore examined AS3 alterations by PCR-SSCP and RT-PCR. Although polymorphisms were found in exon 10 and introns 21, 23, 25 and 29, a possible tumor specific mutation in exon 6 was identified in only one of 31 ESC-derived cell lines, indicating that the remaining allele of AS3 was rarely inactivated by mutational events. Interestingly, ESC patients with rare alleles frequently exhibited lymph node metastasis. These results suggest that polymorphic variation and LOH at the AS3 locus might be associated with lymph node involvement in ESC.

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Copy and paste a formatted citation
Spandidos Publications style
Harada H, Uchida N, Shimada Y, Kumimoto H, Shinoda M, Imamura M and Ishizaki K: Polymorphism and allelic loss at the AS3 locus on 13q12-13 in esophageal squamous cell carcinoma. Int J Oncol 18: 1003-1007, 2001.
APA
Harada, H., Uchida, N., Shimada, Y., Kumimoto, H., Shinoda, M., Imamura, M., & Ishizaki, K. (2001). Polymorphism and allelic loss at the AS3 locus on 13q12-13 in esophageal squamous cell carcinoma. International Journal of Oncology, 18, 1003-1007. https://doi.org/10.3892/ijo.18.5.1003
MLA
Harada, H., Uchida, N., Shimada, Y., Kumimoto, H., Shinoda, M., Imamura, M., Ishizaki, K."Polymorphism and allelic loss at the AS3 locus on 13q12-13 in esophageal squamous cell carcinoma". International Journal of Oncology 18.5 (2001): 1003-1007.
Chicago
Harada, H., Uchida, N., Shimada, Y., Kumimoto, H., Shinoda, M., Imamura, M., Ishizaki, K."Polymorphism and allelic loss at the AS3 locus on 13q12-13 in esophageal squamous cell carcinoma". International Journal of Oncology 18, no. 5 (2001): 1003-1007. https://doi.org/10.3892/ijo.18.5.1003
Copy and paste a formatted citation
x
Spandidos Publications style
Harada H, Uchida N, Shimada Y, Kumimoto H, Shinoda M, Imamura M and Ishizaki K: Polymorphism and allelic loss at the AS3 locus on 13q12-13 in esophageal squamous cell carcinoma. Int J Oncol 18: 1003-1007, 2001.
APA
Harada, H., Uchida, N., Shimada, Y., Kumimoto, H., Shinoda, M., Imamura, M., & Ishizaki, K. (2001). Polymorphism and allelic loss at the AS3 locus on 13q12-13 in esophageal squamous cell carcinoma. International Journal of Oncology, 18, 1003-1007. https://doi.org/10.3892/ijo.18.5.1003
MLA
Harada, H., Uchida, N., Shimada, Y., Kumimoto, H., Shinoda, M., Imamura, M., Ishizaki, K."Polymorphism and allelic loss at the AS3 locus on 13q12-13 in esophageal squamous cell carcinoma". International Journal of Oncology 18.5 (2001): 1003-1007.
Chicago
Harada, H., Uchida, N., Shimada, Y., Kumimoto, H., Shinoda, M., Imamura, M., Ishizaki, K."Polymorphism and allelic loss at the AS3 locus on 13q12-13 in esophageal squamous cell carcinoma". International Journal of Oncology 18, no. 5 (2001): 1003-1007. https://doi.org/10.3892/ijo.18.5.1003
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