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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 2001 Volume 18 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2001 Volume 18 Issue 5

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Article

Detection of MMTV-like LTR and LTR-env gene sequences in human breast cancer

  • Authors:
    • Yue Wang
    • Isabelle Pelisson
    • Stella M. Melana
    • James F. Holland
    • Beatriz G.-T. Pogo

  • View Affiliations / Copyright

    Affiliations: Mechanism of Disease Therapy Program, Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA
  • Pages: 1041-1044
    |
    Published online on: May 1, 2001
       https://doi.org/10.3892/ijo.18.5.1041
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Abstract

We have previously reported, using the polymerase chain reaction (PCR), the presence of a 660 bp sequence homologous to the env gene of MMTV in 38% of the human breast cancers studied, but not in normal breasts nor in other tumors or tissues. We have now investigated the presence of MMTV-like LTR sequences in human breast cancer and normal breast tissue. Primers were selected to amplify a 630 bp sequence homologous to MMTV, but not to the endogenous retrovirus HERV-K10. This sequence was detected in 41.5% of the breast cancers and none of the normal breasts. A larger 1.2 kb LTR fragment was also amplified with high homology to MMTV. Finally, a 1.6 kb fragment containing env and LTR sequences was amplified, cloned and sequenced from breast cancer DNA. The human LTRs were highly homologous to MMTV contain enhancer and promoter elements, the glucocorticoid responsive element (GRE) and the superantigen (Sag) sequences. Presence of functional sequences implies involvement in transcriptional regulation, whereas presence of an env-LTR sequence indicates contiguity within the genome of a potential provirus. Their presence in breast cancer DNA, but not in normal tissue, suggest an exogenous origin.

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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Pelisson I, Melana SM, Holland JF and Pogo BG: Detection of MMTV-like LTR and LTR-env gene sequences in human breast cancer. Int J Oncol 18: 1041-1044, 2001.
APA
Wang, Y., Pelisson, I., Melana, S.M., Holland, J.F., & Pogo, B.G. (2001). Detection of MMTV-like LTR and LTR-env gene sequences in human breast cancer. International Journal of Oncology, 18, 1041-1044. https://doi.org/10.3892/ijo.18.5.1041
MLA
Wang, Y., Pelisson, I., Melana, S. M., Holland, J. F., Pogo, B. G."Detection of MMTV-like LTR and LTR-env gene sequences in human breast cancer". International Journal of Oncology 18.5 (2001): 1041-1044.
Chicago
Wang, Y., Pelisson, I., Melana, S. M., Holland, J. F., Pogo, B. G."Detection of MMTV-like LTR and LTR-env gene sequences in human breast cancer". International Journal of Oncology 18, no. 5 (2001): 1041-1044. https://doi.org/10.3892/ijo.18.5.1041
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Pelisson I, Melana SM, Holland JF and Pogo BG: Detection of MMTV-like LTR and LTR-env gene sequences in human breast cancer. Int J Oncol 18: 1041-1044, 2001.
APA
Wang, Y., Pelisson, I., Melana, S.M., Holland, J.F., & Pogo, B.G. (2001). Detection of MMTV-like LTR and LTR-env gene sequences in human breast cancer. International Journal of Oncology, 18, 1041-1044. https://doi.org/10.3892/ijo.18.5.1041
MLA
Wang, Y., Pelisson, I., Melana, S. M., Holland, J. F., Pogo, B. G."Detection of MMTV-like LTR and LTR-env gene sequences in human breast cancer". International Journal of Oncology 18.5 (2001): 1041-1044.
Chicago
Wang, Y., Pelisson, I., Melana, S. M., Holland, J. F., Pogo, B. G."Detection of MMTV-like LTR and LTR-env gene sequences in human breast cancer". International Journal of Oncology 18, no. 5 (2001): 1041-1044. https://doi.org/10.3892/ijo.18.5.1041
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