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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 2001 Volume 18 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2001 Volume 18 Issue 5

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Article

Characterization of CD44 splicing patterns in normal keratinocytes, dysplastic and squamous carcinoma cell lines

  • Authors:
    • Balvinder K. Bloor
    • Mohsen Jelvagharan
    • Kenneth N. White
    • Edward W. Odell

  • View Affiliations / Copyright

    Affiliations: Head & Neck Cancer Research Program, Guy's, King's & St. Thomas' Dental Institute, King's College London, UK
  • Pages: 1053-1059
    |
    Published online on: May 1, 2001
       https://doi.org/10.3892/ijo.18.5.1053
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Abstract

The CD44 glycoprotein is spliced from a complex gene of 10 constitutive and 10 variant exons. In this study, CD44 splicing patterns and intron 9 retention were investigated by exon-specific RT-PCR for variant exons v1-v10 and intron 9 in normal, immortalized, dysplastic and malignant keratinocytes. Expression of product was determined immunohistochemically for some of the exons. Normal keratinocytes showed one major transcript including exons v2-v10 and 3 minor transcripts. No lines showed a normal CD44 splicing pattern but rather a variety of truncated transcripts of contiguous variant exons which overall correlated with expression. Squamous cell carcinoma (SCC)-4 and SCC-9 lines showed relatively normal transcripts although protein was expressed only by SCC-9. SCC-12B2, SCC-15, SCC-25 and SCC-27 showed a series of shorter overlapping transcripts, with loss of exons v8-v10 in the major transcripts. Intron 9 was not retained in normal keratinocytes or cell lines. Despite the fact that keratinocytes constitutively express all variant exons, splicing patterns are distinctly abnormal and merit investigation as potential markers for epidermal and oral squamous malignancy.

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Copy and paste a formatted citation
Spandidos Publications style
Bloor BK, Jelvagharan M, White KN and Odell EW: Characterization of CD44 splicing patterns in normal keratinocytes, dysplastic and squamous carcinoma cell lines. Int J Oncol 18: 1053-1059, 2001.
APA
Bloor, B.K., Jelvagharan, M., White, K.N., & Odell, E.W. (2001). Characterization of CD44 splicing patterns in normal keratinocytes, dysplastic and squamous carcinoma cell lines. International Journal of Oncology, 18, 1053-1059. https://doi.org/10.3892/ijo.18.5.1053
MLA
Bloor, B. K., Jelvagharan, M., White, K. N., Odell, E. W."Characterization of CD44 splicing patterns in normal keratinocytes, dysplastic and squamous carcinoma cell lines". International Journal of Oncology 18.5 (2001): 1053-1059.
Chicago
Bloor, B. K., Jelvagharan, M., White, K. N., Odell, E. W."Characterization of CD44 splicing patterns in normal keratinocytes, dysplastic and squamous carcinoma cell lines". International Journal of Oncology 18, no. 5 (2001): 1053-1059. https://doi.org/10.3892/ijo.18.5.1053
Copy and paste a formatted citation
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Spandidos Publications style
Bloor BK, Jelvagharan M, White KN and Odell EW: Characterization of CD44 splicing patterns in normal keratinocytes, dysplastic and squamous carcinoma cell lines. Int J Oncol 18: 1053-1059, 2001.
APA
Bloor, B.K., Jelvagharan, M., White, K.N., & Odell, E.W. (2001). Characterization of CD44 splicing patterns in normal keratinocytes, dysplastic and squamous carcinoma cell lines. International Journal of Oncology, 18, 1053-1059. https://doi.org/10.3892/ijo.18.5.1053
MLA
Bloor, B. K., Jelvagharan, M., White, K. N., Odell, E. W."Characterization of CD44 splicing patterns in normal keratinocytes, dysplastic and squamous carcinoma cell lines". International Journal of Oncology 18.5 (2001): 1053-1059.
Chicago
Bloor, B. K., Jelvagharan, M., White, K. N., Odell, E. W."Characterization of CD44 splicing patterns in normal keratinocytes, dysplastic and squamous carcinoma cell lines". International Journal of Oncology 18, no. 5 (2001): 1053-1059. https://doi.org/10.3892/ijo.18.5.1053
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