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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2001 Volume 18 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2001 Volume 18 Issue 6

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Article

Bcl-2 modulates Fas-mediated apoptosis in human renal cell carcinoma cell lines

  • Authors:
    • I. Hara
    • S. Hara
    • H. Miyake
    • S. Arakawa
    • S. Kamidono

  • View Affiliations / Copyright

    Affiliations: Department of Urology, Kobe University School of Medicine, Kobe 650-0017, Japan
  • Pages: 1181-1185
    |
    Published online on: June 1, 2001
       https://doi.org/10.3892/ijo.18.6.1181
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Abstract

The objective of this study was to characterize the role of Bcl-2 expression in Fas-mediated apoptosis in human renal cell carcinoma (RCC) cell lines. RT-PCR analyses showed that 10 different RCC cell lines expressed Fas, but not Fas ligand. Seven of 10 cell lines expressed Fas strongly, while 3 cell lines weakly expressed Fas by flow cytometric analyses. Measurement of the LDH concentration in the culture supernatant revealed that 6 of the 7 cell lines which expressed Fas strongly were sensitive to treatment with an agonistic anti-Fas monoclonal antibody (CH11), whereas all cell lines which weakly expressed Fas did not show Fas-mediated cell death. Furthermore, Bcl-2 expression was found only in three cell lines which were all susceptible to CH11, and the downregulation of Bcl-2 protein by treatment with antisense oligodeoxynucleotide targeting Bcl-2 gene resulted in an enhancement of cell death induced by CH11. These findings suggest that strong Fas expression is necessary for Fas-mediated cell death in RCC cell lines, and Bcl-2 has a protective role against treatment with an anti-Fas monoclonal antibody, despite the fact that Bcl-2 expression was observed only in sensitive cell lines to Fas-mediated cell death.

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Copy and paste a formatted citation
Spandidos Publications style
Hara I, Hara S, Miyake H, Arakawa S and Kamidono S: Bcl-2 modulates Fas-mediated apoptosis in human renal cell carcinoma cell lines. Int J Oncol 18: 1181-1185, 2001.
APA
Hara, I., Hara, S., Miyake, H., Arakawa, S., & Kamidono, S. (2001). Bcl-2 modulates Fas-mediated apoptosis in human renal cell carcinoma cell lines. International Journal of Oncology, 18, 1181-1185. https://doi.org/10.3892/ijo.18.6.1181
MLA
Hara, I., Hara, S., Miyake, H., Arakawa, S., Kamidono, S."Bcl-2 modulates Fas-mediated apoptosis in human renal cell carcinoma cell lines". International Journal of Oncology 18.6 (2001): 1181-1185.
Chicago
Hara, I., Hara, S., Miyake, H., Arakawa, S., Kamidono, S."Bcl-2 modulates Fas-mediated apoptosis in human renal cell carcinoma cell lines". International Journal of Oncology 18, no. 6 (2001): 1181-1185. https://doi.org/10.3892/ijo.18.6.1181
Copy and paste a formatted citation
x
Spandidos Publications style
Hara I, Hara S, Miyake H, Arakawa S and Kamidono S: Bcl-2 modulates Fas-mediated apoptosis in human renal cell carcinoma cell lines. Int J Oncol 18: 1181-1185, 2001.
APA
Hara, I., Hara, S., Miyake, H., Arakawa, S., & Kamidono, S. (2001). Bcl-2 modulates Fas-mediated apoptosis in human renal cell carcinoma cell lines. International Journal of Oncology, 18, 1181-1185. https://doi.org/10.3892/ijo.18.6.1181
MLA
Hara, I., Hara, S., Miyake, H., Arakawa, S., Kamidono, S."Bcl-2 modulates Fas-mediated apoptosis in human renal cell carcinoma cell lines". International Journal of Oncology 18.6 (2001): 1181-1185.
Chicago
Hara, I., Hara, S., Miyake, H., Arakawa, S., Kamidono, S."Bcl-2 modulates Fas-mediated apoptosis in human renal cell carcinoma cell lines". International Journal of Oncology 18, no. 6 (2001): 1181-1185. https://doi.org/10.3892/ijo.18.6.1181
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