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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2001 Volume 18 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2001 Volume 18 Issue 6

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Article

Microsatellite instability correlates with normal expression of cyclin E in hepatocellular carcinomas

  • Authors:
    • I. Nozaki
    • R. Ohashi
    • N. Matsubara
    • R. Hirai
    • A. Andou
    • M. Miyazaki
    • N. Shimizu
    • M. Namba
  • View Affiliations / Copyright

    Affiliations: Department of Cell Biology, Institute of Cellular and Molecular Biology, Okayama University Medical School, Okayama 700-8558, Japan
  • Pages: 1265-1269
    |
    Published online on: June 1, 2001
       https://doi.org/10.3892/ijo.18.6.1265
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Abstract

It has been reported that microsatellite instability (MSI) strongly correlates with carcinogenesis and cancer progression. In the present study, we studied the incidence of MSI at 5 polymorphic microsatellite markers (D5S406, D13S153, D16S402, D17S796, and poly(A) tract BAT26), the expression of G1 cyclins (cyclin A, cyclin D and cyclin E), and Ki-67 labeling index in 30 surgically resected hepatocellular carcinomas (HCCs) and their adjacent non-cancerous tissues. The results of analysis showed that 43% of HCCs exhibited MSI in one locus, 10% in two loci, and 3% in three loci. Overexpressions of cyclin E and cyclin A were observed in 57% and 83% of HCCs, respectively. MSI in HCCs, however, correlated with normal expressions of cyclin E and cyclin A and with a low labeling index of Ki-67. Thus, patients with HCCs exhibiting MSI at these 5 markers may have less involvement of G1/S disregulation and may have better prognosis than other patients with HCC.

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Copy and paste a formatted citation
Spandidos Publications style
Nozaki I, Ohashi R, Matsubara N, Hirai R, Andou A, Miyazaki M, Shimizu N and Namba M: Microsatellite instability correlates with normal expression of cyclin E in hepatocellular carcinomas. Int J Oncol 18: 1265-1269, 2001.
APA
Nozaki, I., Ohashi, R., Matsubara, N., Hirai, R., Andou, A., Miyazaki, M. ... Namba, M. (2001). Microsatellite instability correlates with normal expression of cyclin E in hepatocellular carcinomas. International Journal of Oncology, 18, 1265-1269. https://doi.org/10.3892/ijo.18.6.1265
MLA
Nozaki, I., Ohashi, R., Matsubara, N., Hirai, R., Andou, A., Miyazaki, M., Shimizu, N., Namba, M."Microsatellite instability correlates with normal expression of cyclin E in hepatocellular carcinomas". International Journal of Oncology 18.6 (2001): 1265-1269.
Chicago
Nozaki, I., Ohashi, R., Matsubara, N., Hirai, R., Andou, A., Miyazaki, M., Shimizu, N., Namba, M."Microsatellite instability correlates with normal expression of cyclin E in hepatocellular carcinomas". International Journal of Oncology 18, no. 6 (2001): 1265-1269. https://doi.org/10.3892/ijo.18.6.1265
Copy and paste a formatted citation
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Spandidos Publications style
Nozaki I, Ohashi R, Matsubara N, Hirai R, Andou A, Miyazaki M, Shimizu N and Namba M: Microsatellite instability correlates with normal expression of cyclin E in hepatocellular carcinomas. Int J Oncol 18: 1265-1269, 2001.
APA
Nozaki, I., Ohashi, R., Matsubara, N., Hirai, R., Andou, A., Miyazaki, M. ... Namba, M. (2001). Microsatellite instability correlates with normal expression of cyclin E in hepatocellular carcinomas. International Journal of Oncology, 18, 1265-1269. https://doi.org/10.3892/ijo.18.6.1265
MLA
Nozaki, I., Ohashi, R., Matsubara, N., Hirai, R., Andou, A., Miyazaki, M., Shimizu, N., Namba, M."Microsatellite instability correlates with normal expression of cyclin E in hepatocellular carcinomas". International Journal of Oncology 18.6 (2001): 1265-1269.
Chicago
Nozaki, I., Ohashi, R., Matsubara, N., Hirai, R., Andou, A., Miyazaki, M., Shimizu, N., Namba, M."Microsatellite instability correlates with normal expression of cyclin E in hepatocellular carcinomas". International Journal of Oncology 18, no. 6 (2001): 1265-1269. https://doi.org/10.3892/ijo.18.6.1265
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