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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2001 Volume 19 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2001 Volume 19 Issue 1

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Article

Molecular cloning and characterization of human WNT8A

  • Authors:
    • Tetsuroh Saitoh
    • Masaru Katoh

  • View Affiliations / Copyright

    Affiliations: Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tokyo 104-0045, Japan
  • Pages: 123-127
    |
    Published online on: July 1, 2001
       https://doi.org/10.3892/ijo.19.1.123
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Abstract

WNT - β-catenin - TCF pathway is involved in carcinogenesis and fetal development. Xenopus wnt-8 is one of the most potent Wnts with the capacity to activate β-catenin - TCF pathway in the Xenopus axis duplication assay. Here, we have cloned and characterized WNT8A, a novel human homologue of Xenopus wnt-8. The WNT8A gene, consisting of at least 6 exons, was found to encode a 351-amino-acid polypeptide with the N-terminal signal peptide, three N-linked glycosylation sites, and conserved amino-acid residues of the WNT family. WNT8A showed 63.2% total-amino-acid identity to WNT8B. C-terminal region of WNT8A, WNT8B, WNT2, WNT2B1 and WNT2B2 were longer than that of other WNTs. Among various normal human tissues and 34 human cancer cells lines, the 3.5-kb WNT8A mRNA was detected only in a human teratocarcinoma cell line NT2. These results strongly suggest that WNT8A might be implicated in development of early embryos as well as germ cell tumors through activation of the WNT - β-catenin - TCF pathway.

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Copy and paste a formatted citation
Spandidos Publications style
Saitoh T and Katoh M: Molecular cloning and characterization of human WNT8A. Int J Oncol 19: 123-127, 2001.
APA
Saitoh, T., & Katoh, M. (2001). Molecular cloning and characterization of human WNT8A. International Journal of Oncology, 19, 123-127. https://doi.org/10.3892/ijo.19.1.123
MLA
Saitoh, T., Katoh, M."Molecular cloning and characterization of human WNT8A". International Journal of Oncology 19.1 (2001): 123-127.
Chicago
Saitoh, T., Katoh, M."Molecular cloning and characterization of human WNT8A". International Journal of Oncology 19, no. 1 (2001): 123-127. https://doi.org/10.3892/ijo.19.1.123
Copy and paste a formatted citation
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Spandidos Publications style
Saitoh T and Katoh M: Molecular cloning and characterization of human WNT8A. Int J Oncol 19: 123-127, 2001.
APA
Saitoh, T., & Katoh, M. (2001). Molecular cloning and characterization of human WNT8A. International Journal of Oncology, 19, 123-127. https://doi.org/10.3892/ijo.19.1.123
MLA
Saitoh, T., Katoh, M."Molecular cloning and characterization of human WNT8A". International Journal of Oncology 19.1 (2001): 123-127.
Chicago
Saitoh, T., Katoh, M."Molecular cloning and characterization of human WNT8A". International Journal of Oncology 19, no. 1 (2001): 123-127. https://doi.org/10.3892/ijo.19.1.123
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