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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2001 Volume 19 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2001 Volume 19 Issue 1

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Article

Down-regulation of the desmosomal cadherin desmocollin 3 in human breast cancer

  • Authors:
    • Gregory T. Klus
    • Nina Rokaeus
    • Michael L. Bittner
    • Yidong Chen
    • Dorian M. Korz
    • Saraswati Sukumar
    • Ari Schick
    • Zoltan Szallasi

  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799, USA
  • Pages: 169-174
    |
    Published online on: July 1, 2001
       https://doi.org/10.3892/ijo.19.1.169
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Abstract

In previous studies using cDNA microarray analysis, we have identified an expressed sequence tag which is consistently down-regulated in six human breast tumor cell lines. In the current study, we have determined this tag to be part of the mRNA sequence of human desmocollin 3, a member of the cadherin superfamily of proteins and an integral component of desmosomes. Desmosomes are sites of adhesion between adjacent cells in layers of epithelia, as well as in some non-epithelial tissues, and play an important role in the maintenance of tissue structure. Northern analysis, quantitative real-time polymerase chain reaction assay and Western blot analysis showed that desmocollin 3 is present in normal and immortalized human mammary epithelial cells, but consistently exhibits a significant, and often complete, down-regulation in breast cancer cell lines and primary breast tumors, both at the mRNA and protein levels.

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Copy and paste a formatted citation
Spandidos Publications style
Klus GT, Rokaeus N, Bittner ML, Chen Y, Korz DM, Sukumar S, Schick A and Szallasi Z: Down-regulation of the desmosomal cadherin desmocollin 3 in human breast cancer. Int J Oncol 19: 169-174, 2001.
APA
Klus, G.T., Rokaeus, N., Bittner, M.L., Chen, Y., Korz, D.M., Sukumar, S. ... Szallasi, Z. (2001). Down-regulation of the desmosomal cadherin desmocollin 3 in human breast cancer. International Journal of Oncology, 19, 169-174. https://doi.org/10.3892/ijo.19.1.169
MLA
Klus, G. T., Rokaeus, N., Bittner, M. L., Chen, Y., Korz, D. M., Sukumar, S., Schick, A., Szallasi, Z."Down-regulation of the desmosomal cadherin desmocollin 3 in human breast cancer". International Journal of Oncology 19.1 (2001): 169-174.
Chicago
Klus, G. T., Rokaeus, N., Bittner, M. L., Chen, Y., Korz, D. M., Sukumar, S., Schick, A., Szallasi, Z."Down-regulation of the desmosomal cadherin desmocollin 3 in human breast cancer". International Journal of Oncology 19, no. 1 (2001): 169-174. https://doi.org/10.3892/ijo.19.1.169
Copy and paste a formatted citation
x
Spandidos Publications style
Klus GT, Rokaeus N, Bittner ML, Chen Y, Korz DM, Sukumar S, Schick A and Szallasi Z: Down-regulation of the desmosomal cadherin desmocollin 3 in human breast cancer. Int J Oncol 19: 169-174, 2001.
APA
Klus, G.T., Rokaeus, N., Bittner, M.L., Chen, Y., Korz, D.M., Sukumar, S. ... Szallasi, Z. (2001). Down-regulation of the desmosomal cadherin desmocollin 3 in human breast cancer. International Journal of Oncology, 19, 169-174. https://doi.org/10.3892/ijo.19.1.169
MLA
Klus, G. T., Rokaeus, N., Bittner, M. L., Chen, Y., Korz, D. M., Sukumar, S., Schick, A., Szallasi, Z."Down-regulation of the desmosomal cadherin desmocollin 3 in human breast cancer". International Journal of Oncology 19.1 (2001): 169-174.
Chicago
Klus, G. T., Rokaeus, N., Bittner, M. L., Chen, Y., Korz, D. M., Sukumar, S., Schick, A., Szallasi, Z."Down-regulation of the desmosomal cadherin desmocollin 3 in human breast cancer". International Journal of Oncology 19, no. 1 (2001): 169-174. https://doi.org/10.3892/ijo.19.1.169
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