Differential expression of class I HDACs: Roles of cell density and cell cycle

Dangond,F.; Henriksson,M.; Zardo,G.; Caiafa,P.; Ekstrom,T. J.; Gray,S. G.

doi:10.3892/ijo.19.4.773

October 2001 Volume 19 Issue 4

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October 2001 Volume 19 Issue 4

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Article

Differential expression of class I HDACs: Roles of cell density and cell cycle

Authors:
- F. Dangond
- M. Henriksson
- G. Zardo
- P. Caiafa
- T. J. Ekstrom
- S. G. Gray
View Affiliations / Copyright

Affiliations: Laboratory of Transcriptional and Immune Regulation, Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
Pages: 773-777
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Published online on: October 1, 2001

https://doi.org/10.3892/ijo.19.4.773
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Abstract

Enzymes which affect histone acetylation status have been shown to play an important role in determining transcriptional activity in chromatin through conformational modification of its structure. Since the timely presence of such enzymes may be of critical importance, our experiments were designed to determine whether the level of expression of HDAC1 is cell cycle dependent and/or affected by a high cell density. Our results show that in mouse fibroblasts the expression of mHDAC1 is neither affected by cell cycle phases nor by cell density. In contrast, the expression of several hHDACs including hHDAC1 were affected in a cell density dependent fashion in the human prostate adenocarcinoma cell line PC3, paralleling our previously published findings in the hepatocellular carcinoma derived cell line Hep3B. Differential recruitment of HDAC mRNAs suggests that these enzymes may play unique roles in different cell types and under different environmental conditions (i.e., exposure to various cell densities and cell-cell contacts). Our study has implications for the proposed use of HDAC inhibitors in the treatment of human malignancy, highlighting issues of drug action selectivity in tissues and potential secondary effects.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Differential expression of class I HDACs: Roles of cell density and cell cycle

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Abstract

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