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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 2001 Volume 19 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2001 Volume 19 Issue 4

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Article

DNA repair-redox enzyme apurinic endonuclease in cervical cancer: Evaluation of redox control of HIF-1α and prognostic significance

  • Authors:
    • Monika Schindl
    • Georg Oberhuber
    • Ernest G. Pichlbauer
    • Andreas Obermair
    • Peter Birner
    • Mark R. Kelley

  • View Affiliations / Copyright

    Affiliations: Institute of Clinical Pathology, University of Vienna, Vienna, Austria
  • Pages: 799-802
    |
    Published online on: October 1, 2001
       https://doi.org/10.3892/ijo.19.4.799
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Abstract

The multifunctional apurinic/apyrimidinic endonuclease (Ape1/ref-1) plays a key role in the human DNA base excision repair pathway. Ape1/ref-1 has also been shown to be involved in the redox control of transactivation activities of hypoxia-inducible factor (HIF)-1α. The aim of our study was to investigate the expression of these proteins in early stage invasive cervical cancer. Expression of Ape1/ref-1 and HIF-1α was detected immunohistochemically in 88 samples of cervical cancer stage pT1b. The levels of the proteins were compared and the prognostic influence of Ape1/ref-1 expression was investigated. Strong nuclear expression of Ape1/ref-1 was observed in 9 cases (10.2%), moderate in 22 cases (25%), weak in 17 cases (19.3%), and absent in 40 cases (45.5%). Furthermore, no correlation between Ape1/ref-1 and HIF-1α expression was observed (p=0.864). We also found no relationship of Ape1/ref-1 expression and survival (p>0.05, log-rank test). From these studies, we have concluded that in cervical cancer there is no correlation between the upstream redox regulatory protein of HIF-1, i.e., Ape1/ref-1, and HIF-1α expression. However, these studies do not address any functional relationship between the two proteins.

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Copy and paste a formatted citation
Spandidos Publications style
Schindl M, Oberhuber G, Pichlbauer EG, Obermair A, Birner P and Kelley MR: DNA repair-redox enzyme apurinic endonuclease in cervical cancer: Evaluation of redox control of HIF-1α and prognostic significance. Int J Oncol 19: 799-802, 2001.
APA
Schindl, M., Oberhuber, G., Pichlbauer, E.G., Obermair, A., Birner, P., & Kelley, M.R. (2001). DNA repair-redox enzyme apurinic endonuclease in cervical cancer: Evaluation of redox control of HIF-1α and prognostic significance. International Journal of Oncology, 19, 799-802. https://doi.org/10.3892/ijo.19.4.799
MLA
Schindl, M., Oberhuber, G., Pichlbauer, E. G., Obermair, A., Birner, P., Kelley, M. R."DNA repair-redox enzyme apurinic endonuclease in cervical cancer: Evaluation of redox control of HIF-1α and prognostic significance". International Journal of Oncology 19.4 (2001): 799-802.
Chicago
Schindl, M., Oberhuber, G., Pichlbauer, E. G., Obermair, A., Birner, P., Kelley, M. R."DNA repair-redox enzyme apurinic endonuclease in cervical cancer: Evaluation of redox control of HIF-1α and prognostic significance". International Journal of Oncology 19, no. 4 (2001): 799-802. https://doi.org/10.3892/ijo.19.4.799
Copy and paste a formatted citation
x
Spandidos Publications style
Schindl M, Oberhuber G, Pichlbauer EG, Obermair A, Birner P and Kelley MR: DNA repair-redox enzyme apurinic endonuclease in cervical cancer: Evaluation of redox control of HIF-1α and prognostic significance. Int J Oncol 19: 799-802, 2001.
APA
Schindl, M., Oberhuber, G., Pichlbauer, E.G., Obermair, A., Birner, P., & Kelley, M.R. (2001). DNA repair-redox enzyme apurinic endonuclease in cervical cancer: Evaluation of redox control of HIF-1α and prognostic significance. International Journal of Oncology, 19, 799-802. https://doi.org/10.3892/ijo.19.4.799
MLA
Schindl, M., Oberhuber, G., Pichlbauer, E. G., Obermair, A., Birner, P., Kelley, M. R."DNA repair-redox enzyme apurinic endonuclease in cervical cancer: Evaluation of redox control of HIF-1α and prognostic significance". International Journal of Oncology 19.4 (2001): 799-802.
Chicago
Schindl, M., Oberhuber, G., Pichlbauer, E. G., Obermair, A., Birner, P., Kelley, M. R."DNA repair-redox enzyme apurinic endonuclease in cervical cancer: Evaluation of redox control of HIF-1α and prognostic significance". International Journal of Oncology 19, no. 4 (2001): 799-802. https://doi.org/10.3892/ijo.19.4.799
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