Potent anti-metastatic activity of combretastatin-A4

  • Authors:
    • Jeremy Griggs
    • Kevin M. Brindle
    • James C. Metcalfe
    • Sally A. Hill
    • Gerry A. Smith
    • Daniel A. Beauregard
    • Robin Hesketh
  • View Affiliations

  • Published online on: October 1, 2001     https://doi.org/10.3892/ijo.19.4.821
  • Pages: 821-825
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Abstract

The requirement for tumour vascularisation to permit the expansion of solid tumours beyond a threshold size of approximately 1 mm diameter has focussed attention on anti-vascular and anti-angiogenic agents for cancer therapy. Combretastatin-A4 (cis CA-4P) is a tubulin-binding agent that is cytotoxic for proliferating endothelial cells in vitro and causes anti-vascular effects in the established tumour vessels of some primary tumours. Preliminary data from Phase I clinical trials indicate that cis CA-4 may also be effective in targeting the vasculature of human tumours. As metastatic disease is the principal cause of mortality in cancer, we have investigated the effects of cis CA-4 on metastatic development using an in vivo model. We show that bolus or continuous administration of cis CA-4P results in potent inhibition of metastases derived from ectopic primary Lewis lung carcinomas in mice whereas the trans CA-4 isomer is without effect. These data further characterise the activity of CA-4 in vivo and suggest that the drug should be evaluated clinically as an anti-metastatic agent.

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October 2001
Volume 19 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Griggs J, Brindle KM, Metcalfe JC, Hill SA, Smith GA, Beauregard DA and Hesketh R: Potent anti-metastatic activity of combretastatin-A4. Int J Oncol 19: 821-825, 2001
APA
Griggs, J., Brindle, K.M., Metcalfe, J.C., Hill, S.A., Smith, G.A., Beauregard, D.A., & Hesketh, R. (2001). Potent anti-metastatic activity of combretastatin-A4. International Journal of Oncology, 19, 821-825. https://doi.org/10.3892/ijo.19.4.821
MLA
Griggs, J., Brindle, K. M., Metcalfe, J. C., Hill, S. A., Smith, G. A., Beauregard, D. A., Hesketh, R."Potent anti-metastatic activity of combretastatin-A4". International Journal of Oncology 19.4 (2001): 821-825.
Chicago
Griggs, J., Brindle, K. M., Metcalfe, J. C., Hill, S. A., Smith, G. A., Beauregard, D. A., Hesketh, R."Potent anti-metastatic activity of combretastatin-A4". International Journal of Oncology 19, no. 4 (2001): 821-825. https://doi.org/10.3892/ijo.19.4.821