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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2001 Volume 19 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2001 Volume 19 Issue 5

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Article

Molecular cloning and characterization of WNT14B, a novel member of the WNT gene family

  • Authors:
    • Hiroyuki Kirikoshi
    • Hisahiko Sekihara
    • Masaru Katoh

  • View Affiliations / Copyright

    Affiliations: Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tokyo 104-0045, Japan
  • Pages: 947-952
    |
    Published online on: November 1, 2001
       https://doi.org/10.3892/ijo.19.5.947
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Abstract

WNT14B was cloned and characterized in this study. WNT14B encoded 357-amino acid WNT family protein with the signal peptide and an N-linked glycosylation site. WNT14B was most homologous to WNT14 (61.4% total amino acid identity). WNT15 cDNA fragment previously isolated by another group corresponds to a part of ORF of the WNT14B cDNA (codon 216-335). Exon-intron boundaries were conserved between WNT14B and WNT14 genes. WNT14B and WNT3 genes were clustered in the human chromosome 17q21 region in head to head manner. Intergenic region between WNT14B and WNT3 genes was about 33 kb in size. The 6.6-kb WNT14B mRNA was moderately expressed in fetal kidney and adult kidney. Although WNT14B mRNA was not detected in fetal brain and adult brain by northern blot analyses, WNT14B mRNA was detected in brain, especially in occipital lobe, by RNA dot blot analysis. Among 48 human cancer cell lines derived from various tissues, WNT14B was expressed in a teratocarcinoma cell line NT2 with the potential to differentiate into neuronal cells. WNT14B mRNA was significantly up-regulated by all-trans retinoic acid in NT2 cells. These results strongly suggest that WNT14B might be implicated in the early process of neuronal differentiation of NT2 cells induced by retinoic acid.

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Copy and paste a formatted citation
Spandidos Publications style
Kirikoshi H, Sekihara H and Katoh M: Molecular cloning and characterization of WNT14B, a novel member of the WNT gene family. Int J Oncol 19: 947-952, 2001.
APA
Kirikoshi, H., Sekihara, H., & Katoh, M. (2001). Molecular cloning and characterization of WNT14B, a novel member of the WNT gene family. International Journal of Oncology, 19, 947-952. https://doi.org/10.3892/ijo.19.5.947
MLA
Kirikoshi, H., Sekihara, H., Katoh, M."Molecular cloning and characterization of WNT14B, a novel member of the WNT gene family". International Journal of Oncology 19.5 (2001): 947-952.
Chicago
Kirikoshi, H., Sekihara, H., Katoh, M."Molecular cloning and characterization of WNT14B, a novel member of the WNT gene family". International Journal of Oncology 19, no. 5 (2001): 947-952. https://doi.org/10.3892/ijo.19.5.947
Copy and paste a formatted citation
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Spandidos Publications style
Kirikoshi H, Sekihara H and Katoh M: Molecular cloning and characterization of WNT14B, a novel member of the WNT gene family. Int J Oncol 19: 947-952, 2001.
APA
Kirikoshi, H., Sekihara, H., & Katoh, M. (2001). Molecular cloning and characterization of WNT14B, a novel member of the WNT gene family. International Journal of Oncology, 19, 947-952. https://doi.org/10.3892/ijo.19.5.947
MLA
Kirikoshi, H., Sekihara, H., Katoh, M."Molecular cloning and characterization of WNT14B, a novel member of the WNT gene family". International Journal of Oncology 19.5 (2001): 947-952.
Chicago
Kirikoshi, H., Sekihara, H., Katoh, M."Molecular cloning and characterization of WNT14B, a novel member of the WNT gene family". International Journal of Oncology 19, no. 5 (2001): 947-952. https://doi.org/10.3892/ijo.19.5.947
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