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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2001 Volume 19 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2001 Volume 19 Issue 6

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Article

The Cockayne syndrome group B DNA repair protein as an anti-cancer target

  • Authors:
    • Y. Lu
    • Sridhar Mani
    • Ekambar R. Kandimalla
    • Dong Yu
    • Sudhir Agrawal
    • J. Christopher States
    • David B. Bregman

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
  • Pages: 1089-1097
    |
    Published online on: December 1, 2001
       https://doi.org/10.3892/ijo.19.6.1089
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Abstract

Cells from individuals with Cockayne syndrome (CS) have a defect in transcription-coupled DNA repair (TCR), which rapidly corrects certain DNA lesions located on the transcribed strand of active genes. Despite this DNA repair defect, individuals with CS (of which there are two complementation groups, CSA and CSB) do not demonstrate an elevated incidence of cancer. Recently, we demonstrated that disruption of the CSB gene reduces the spontaneous tumor rate in cancer predisposed Ink4a/ARF-/- mice as well as causing their embryo fibroblasts to proliferate more slowly and be more sensitive to UV-induced apoptosis. In the present study we characterized phosphorothioate backbone antisense oligodeoxynucleotides (AOs) that reduced the levels of CSB mRNA in A2780/CP70 ovarian carcinoma cells. The AOs caused the cells to proliferate more slowly and made them more sensitive to either cisplatin or oxaliplatin. The AOs also enhanced the cytotoxicity of hydrogen peroxide and γ-radiation, both of which can induce oxidative DNA lesions, which are subject to TCR. The AOs did not potentiate the cytotoxicity of topotecan, which induces DNA strand breaks. Chemically modified () AOs (MBOs) targeting CSB were able to potentiate the anti-tumor effect of cisplatin against A2780/CP70 tumor xenografts formed in nude mice. The MBOs enabled a non-toxic (3 mg/kg) dose of cisplatin to have the same degree of anti-tumor efficacy as a more toxic (5 mg/kg) cisplatin dose. Collectively, these results suggest that the CSB gene product may be viewed as an anti-cancer target.

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Copy and paste a formatted citation
Spandidos Publications style
Lu Y, Mani S, Kandimalla ER, Yu D, Agrawal S, States JC and Bregman DB: The Cockayne syndrome group B DNA repair protein as an anti-cancer target. Int J Oncol 19: 1089-1097, 2001.
APA
Lu, Y., Mani, S., Kandimalla, E.R., Yu, D., Agrawal, S., States, J.C., & Bregman, D.B. (2001). The Cockayne syndrome group B DNA repair protein as an anti-cancer target. International Journal of Oncology, 19, 1089-1097. https://doi.org/10.3892/ijo.19.6.1089
MLA
Lu, Y., Mani, S., Kandimalla, E. R., Yu, D., Agrawal, S., States, J. C., Bregman, D. B."The Cockayne syndrome group B DNA repair protein as an anti-cancer target". International Journal of Oncology 19.6 (2001): 1089-1097.
Chicago
Lu, Y., Mani, S., Kandimalla, E. R., Yu, D., Agrawal, S., States, J. C., Bregman, D. B."The Cockayne syndrome group B DNA repair protein as an anti-cancer target". International Journal of Oncology 19, no. 6 (2001): 1089-1097. https://doi.org/10.3892/ijo.19.6.1089
Copy and paste a formatted citation
x
Spandidos Publications style
Lu Y, Mani S, Kandimalla ER, Yu D, Agrawal S, States JC and Bregman DB: The Cockayne syndrome group B DNA repair protein as an anti-cancer target. Int J Oncol 19: 1089-1097, 2001.
APA
Lu, Y., Mani, S., Kandimalla, E.R., Yu, D., Agrawal, S., States, J.C., & Bregman, D.B. (2001). The Cockayne syndrome group B DNA repair protein as an anti-cancer target. International Journal of Oncology, 19, 1089-1097. https://doi.org/10.3892/ijo.19.6.1089
MLA
Lu, Y., Mani, S., Kandimalla, E. R., Yu, D., Agrawal, S., States, J. C., Bregman, D. B."The Cockayne syndrome group B DNA repair protein as an anti-cancer target". International Journal of Oncology 19.6 (2001): 1089-1097.
Chicago
Lu, Y., Mani, S., Kandimalla, E. R., Yu, D., Agrawal, S., States, J. C., Bregman, D. B."The Cockayne syndrome group B DNA repair protein as an anti-cancer target". International Journal of Oncology 19, no. 6 (2001): 1089-1097. https://doi.org/10.3892/ijo.19.6.1089
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