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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2001 Volume 19 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2001 Volume 19 Issue 6

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Article

FAS-associated factor 1 interacts with protein kinase CK2 in vivo upon apoptosis induction

  • Authors:
    • B. Guerra
    • B. Boldyreff
    • Olaf-Georg Issinger

  • View Affiliations / Copyright

    Affiliations: University of Southern Denmark, Odense University, Institute for Biochemistry and Molecular Biology, DK-5230 Odense, Denmark
  • Pages: 1117-1126
    |
    Published online on: December 1, 2001
       https://doi.org/10.3892/ijo.19.6.1117
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Abstract

We show here that in several different cell lines protein kinase CK2 and Fas-associated factor 1 (FAF1) exist together in a complex which is stable to high monovalent salt concentration. The CK2/FAF1 complex formation is significantly increased after induction of apoptosis with various DNA damaging agents. Interestingly this effect is only seen in cell lines with an embryonic origin and not when cells have entered a differentiated state. It is further shown that the CK2 specific phosphorylation sites in the FAF1 molecule, i.e. serines 289 and 291 influence this complex formation. Mutation of the CK2 phosphorylation sites in the FAF1 molecule to alanine leads to a 1.5 to 2.0-fold higher association between CK2 and FAF1. Since the CK2 activity did not increase concomitantly with the complex formation we conclude that the FAF1 becomes to the CK2 enzyme so that a normal enzyme catalysis does not take place anymore. Subcellular localization experiments involving CK2 subunits and FAF1 show a co-localization of both CK2 subunits and FAF1 in the peri-nuclear cytoplasm. The majority of CK2 subunits is found in the nucleus. FAF1 is also found in the nucleoli. The results obtained further support the view that protein kinase CK2 plays an important role in certain steps of apoptosis.

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Copy and paste a formatted citation
Spandidos Publications style
Guerra B, Boldyreff B and Issinger O: FAS-associated factor 1 interacts with protein kinase CK2 in vivo upon apoptosis induction. Int J Oncol 19: 1117-1126, 2001.
APA
Guerra, B., Boldyreff, B., & Issinger, O. (2001). FAS-associated factor 1 interacts with protein kinase CK2 in vivo upon apoptosis induction. International Journal of Oncology, 19, 1117-1126. https://doi.org/10.3892/ijo.19.6.1117
MLA
Guerra, B., Boldyreff, B., Issinger, O."FAS-associated factor 1 interacts with protein kinase CK2 in vivo upon apoptosis induction". International Journal of Oncology 19.6 (2001): 1117-1126.
Chicago
Guerra, B., Boldyreff, B., Issinger, O."FAS-associated factor 1 interacts with protein kinase CK2 in vivo upon apoptosis induction". International Journal of Oncology 19, no. 6 (2001): 1117-1126. https://doi.org/10.3892/ijo.19.6.1117
Copy and paste a formatted citation
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Spandidos Publications style
Guerra B, Boldyreff B and Issinger O: FAS-associated factor 1 interacts with protein kinase CK2 in vivo upon apoptosis induction. Int J Oncol 19: 1117-1126, 2001.
APA
Guerra, B., Boldyreff, B., & Issinger, O. (2001). FAS-associated factor 1 interacts with protein kinase CK2 in vivo upon apoptosis induction. International Journal of Oncology, 19, 1117-1126. https://doi.org/10.3892/ijo.19.6.1117
MLA
Guerra, B., Boldyreff, B., Issinger, O."FAS-associated factor 1 interacts with protein kinase CK2 in vivo upon apoptosis induction". International Journal of Oncology 19.6 (2001): 1117-1126.
Chicago
Guerra, B., Boldyreff, B., Issinger, O."FAS-associated factor 1 interacts with protein kinase CK2 in vivo upon apoptosis induction". International Journal of Oncology 19, no. 6 (2001): 1117-1126. https://doi.org/10.3892/ijo.19.6.1117
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