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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2001 Volume 19 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2001 Volume 19 Issue 6

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Article

Identification of the prostate cancer micro-foci with chromosome 8p deletion at the tumor interface area by histopathological-FISH parallel examination

  • Authors:
    • Shi-Qi Wu
    • G. Reza Hafez
    • Jianhua Zhang
    • Michael Newton
    • Alice Chen
    • Joan Lange
    • George Wilding

  • View Affiliations / Copyright

    Affiliations: Division of Medical Genetics, Childrens Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA
  • Pages: 1143-1147
    |
    Published online on: December 1, 2001
       https://doi.org/10.3892/ijo.19.6.1143
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Abstract

We used a histopathological-fluorescence in situ hybridization (histo-FISH) parallel examination technique to identify the micro-foci of prostate cancer with chromosome 8p deletion at the interface area adjacent to the tumor. The archival paraffin embedded prostate tissue sections from 27 prostate cancer patients were evaluated. Seventy-eight percent of the patients showed chromosome 8p deletion in the tumor sections. Eight of the 27 patients (30%) had been found positive for tumor micro-foci with chromosome 8p deletion at the tumor interface area. There is a strong trend for patients with late stage tumors to have positive findings for tumor micro-foci at the interface area (p<0.002). Our data suggests that the formation of tumor micro-foci with chromosome 8p deletion and ploidy change at the interface area is a significant development in the advanced prostate cancer, and identification of these micro-foci may serve as a prognostic parameter in the clinical assessment of prostate cancer patients.

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Copy and paste a formatted citation
Spandidos Publications style
Wu S, Hafez GR, Zhang J, Newton M, Chen A, Lange J and Wilding G: Identification of the prostate cancer micro-foci with chromosome 8p deletion at the tumor interface area by histopathological-FISH parallel examination. Int J Oncol 19: 1143-1147, 2001.
APA
Wu, S., Hafez, G.R., Zhang, J., Newton, M., Chen, A., Lange, J., & Wilding, G. (2001). Identification of the prostate cancer micro-foci with chromosome 8p deletion at the tumor interface area by histopathological-FISH parallel examination. International Journal of Oncology, 19, 1143-1147. https://doi.org/10.3892/ijo.19.6.1143
MLA
Wu, S., Hafez, G. R., Zhang, J., Newton, M., Chen, A., Lange, J., Wilding, G."Identification of the prostate cancer micro-foci with chromosome 8p deletion at the tumor interface area by histopathological-FISH parallel examination". International Journal of Oncology 19.6 (2001): 1143-1147.
Chicago
Wu, S., Hafez, G. R., Zhang, J., Newton, M., Chen, A., Lange, J., Wilding, G."Identification of the prostate cancer micro-foci with chromosome 8p deletion at the tumor interface area by histopathological-FISH parallel examination". International Journal of Oncology 19, no. 6 (2001): 1143-1147. https://doi.org/10.3892/ijo.19.6.1143
Copy and paste a formatted citation
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Spandidos Publications style
Wu S, Hafez GR, Zhang J, Newton M, Chen A, Lange J and Wilding G: Identification of the prostate cancer micro-foci with chromosome 8p deletion at the tumor interface area by histopathological-FISH parallel examination. Int J Oncol 19: 1143-1147, 2001.
APA
Wu, S., Hafez, G.R., Zhang, J., Newton, M., Chen, A., Lange, J., & Wilding, G. (2001). Identification of the prostate cancer micro-foci with chromosome 8p deletion at the tumor interface area by histopathological-FISH parallel examination. International Journal of Oncology, 19, 1143-1147. https://doi.org/10.3892/ijo.19.6.1143
MLA
Wu, S., Hafez, G. R., Zhang, J., Newton, M., Chen, A., Lange, J., Wilding, G."Identification of the prostate cancer micro-foci with chromosome 8p deletion at the tumor interface area by histopathological-FISH parallel examination". International Journal of Oncology 19.6 (2001): 1143-1147.
Chicago
Wu, S., Hafez, G. R., Zhang, J., Newton, M., Chen, A., Lange, J., Wilding, G."Identification of the prostate cancer micro-foci with chromosome 8p deletion at the tumor interface area by histopathological-FISH parallel examination". International Journal of Oncology 19, no. 6 (2001): 1143-1147. https://doi.org/10.3892/ijo.19.6.1143
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