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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2001 Volume 19 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2001 Volume 19 Issue 6

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Article

Expression of putative anticancer targets in familial adenomatous polyposis and its association with the APC mutation status

  • Authors:
    • Bostjan Humar
    • Daniel D'Orazio
    • Christiane Albrecht
    • Peter Bauerfeind
    • Hansjakob Muller
    • Zuzana Dobbie
    • Igor Bendik

  • View Affiliations / Copyright

    Affiliations: Division of Medical Genetics, DKBW, Research Group Human Genetics, University Hospital, Basel, Switzerland
  • Pages: 1179-1186
    |
    Published online on: December 1, 2001
       https://doi.org/10.3892/ijo.19.6.1179
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Abstract

Several substances interfering with colorectal carcinogenesis may reduce or prevent adenoma formation in familial adenomatous polyposis (FAP), an inherited predisposition to colorectal cancer. This study determined the expression of genes coding for putative anticancer targets (COX-2, iNOS, MMP-7, ODC, PKCβ, PPARγ, RXRα, RXRβ, RXRγ) in FAP patients to provide one of the rationales for the design of chemotherapy and -prevention strategies. Gene expression was assessed by TaqMan analysis in colonic tissue of 9 FAP patients with mutations in the APC gene (APCpos), 5 FAP patients without identified genetic defect (APCneg), and 3 healthy individuals. Among the examined genes, PKCβ and MMP-7 were most consistently altered in adenoma tissue relative to matched mucosa. Intriguingly, ODC was clearly overexpressed in polyps from APCpos but not APCneg patients. Furthermore, PKCβ, MMP-7, ODC, and COX-2 as well as all RXRs displayed altered expression in apparently healthy FAP mucosa as opposed to that of healthy individuals. Our data suggests PKCβ and MMP-7 to be the most suited as anticancer targets among the genes studied.

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Copy and paste a formatted citation
Spandidos Publications style
Humar B, D'Orazio D, Albrecht C, Bauerfeind P, Muller H, Dobbie Z and Bendik I: Expression of putative anticancer targets in familial adenomatous polyposis and its association with the APC mutation status. Int J Oncol 19: 1179-1186, 2001.
APA
Humar, B., D'Orazio, D., Albrecht, C., Bauerfeind, P., Muller, H., Dobbie, Z., & Bendik, I. (2001). Expression of putative anticancer targets in familial adenomatous polyposis and its association with the APC mutation status. International Journal of Oncology, 19, 1179-1186. https://doi.org/10.3892/ijo.19.6.1179
MLA
Humar, B., D'Orazio, D., Albrecht, C., Bauerfeind, P., Muller, H., Dobbie, Z., Bendik, I."Expression of putative anticancer targets in familial adenomatous polyposis and its association with the APC mutation status". International Journal of Oncology 19.6 (2001): 1179-1186.
Chicago
Humar, B., D'Orazio, D., Albrecht, C., Bauerfeind, P., Muller, H., Dobbie, Z., Bendik, I."Expression of putative anticancer targets in familial adenomatous polyposis and its association with the APC mutation status". International Journal of Oncology 19, no. 6 (2001): 1179-1186. https://doi.org/10.3892/ijo.19.6.1179
Copy and paste a formatted citation
x
Spandidos Publications style
Humar B, D'Orazio D, Albrecht C, Bauerfeind P, Muller H, Dobbie Z and Bendik I: Expression of putative anticancer targets in familial adenomatous polyposis and its association with the APC mutation status. Int J Oncol 19: 1179-1186, 2001.
APA
Humar, B., D'Orazio, D., Albrecht, C., Bauerfeind, P., Muller, H., Dobbie, Z., & Bendik, I. (2001). Expression of putative anticancer targets in familial adenomatous polyposis and its association with the APC mutation status. International Journal of Oncology, 19, 1179-1186. https://doi.org/10.3892/ijo.19.6.1179
MLA
Humar, B., D'Orazio, D., Albrecht, C., Bauerfeind, P., Muller, H., Dobbie, Z., Bendik, I."Expression of putative anticancer targets in familial adenomatous polyposis and its association with the APC mutation status". International Journal of Oncology 19.6 (2001): 1179-1186.
Chicago
Humar, B., D'Orazio, D., Albrecht, C., Bauerfeind, P., Muller, H., Dobbie, Z., Bendik, I."Expression of putative anticancer targets in familial adenomatous polyposis and its association with the APC mutation status". International Journal of Oncology 19, no. 6 (2001): 1179-1186. https://doi.org/10.3892/ijo.19.6.1179
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