Expression of putative anticancer targets in familial adenomatous polyposis and its association with the APC mutation status

  • Authors:
    • Bostjan Humar
    • Daniel D'Orazio
    • Christiane Albrecht
    • Peter Bauerfeind
    • Hansjakob Muller
    • Zuzana Dobbie
    • Igor Bendik
  • View Affiliations

  • Published online on: December 1, 2001     https://doi.org/10.3892/ijo.19.6.1179
  • Pages: 1179-1186
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Several substances interfering with colorectal carcinogenesis may reduce or prevent adenoma formation in familial adenomatous polyposis (FAP), an inherited predisposition to colorectal cancer. This study determined the expression of genes coding for putative anticancer targets (COX-2, iNOS, MMP-7, ODC, PKCβ, PPARγ, RXRα, RXRβ, RXRγ) in FAP patients to provide one of the rationales for the design of chemotherapy and -prevention strategies. Gene expression was assessed by TaqMan analysis in colonic tissue of 9 FAP patients with mutations in the APC gene (APCpos), 5 FAP patients without identified genetic defect (APCneg), and 3 healthy individuals. Among the examined genes, PKCβ and MMP-7 were most consistently altered in adenoma tissue relative to matched mucosa. Intriguingly, ODC was clearly overexpressed in polyps from APCpos but not APCneg patients. Furthermore, PKCβ, MMP-7, ODC, and COX-2 as well as all RXRs displayed altered expression in apparently healthy FAP mucosa as opposed to that of healthy individuals. Our data suggests PKCβ and MMP-7 to be the most suited as anticancer targets among the genes studied.

Related Articles

Journal Cover

December 2001
Volume 19 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Humar B, D'Orazio D, Albrecht C, Bauerfeind P, Muller H, Dobbie Z and Bendik I: Expression of putative anticancer targets in familial adenomatous polyposis and its association with the APC mutation status. Int J Oncol 19: 1179-1186, 2001
APA
Humar, B., D'Orazio, D., Albrecht, C., Bauerfeind, P., Muller, H., Dobbie, Z., & Bendik, I. (2001). Expression of putative anticancer targets in familial adenomatous polyposis and its association with the APC mutation status. International Journal of Oncology, 19, 1179-1186. https://doi.org/10.3892/ijo.19.6.1179
MLA
Humar, B., D'Orazio, D., Albrecht, C., Bauerfeind, P., Muller, H., Dobbie, Z., Bendik, I."Expression of putative anticancer targets in familial adenomatous polyposis and its association with the APC mutation status". International Journal of Oncology 19.6 (2001): 1179-1186.
Chicago
Humar, B., D'Orazio, D., Albrecht, C., Bauerfeind, P., Muller, H., Dobbie, Z., Bendik, I."Expression of putative anticancer targets in familial adenomatous polyposis and its association with the APC mutation status". International Journal of Oncology 19, no. 6 (2001): 1179-1186. https://doi.org/10.3892/ijo.19.6.1179