No improvement in perfusion and oxygenation of experimental tumors upon application of vasodilator drugs

  • Authors:
    • Oliver Thews
    • Debra K. Kelleher
    • Peter Vaupel
  • View Affiliations

  • Published online on: December 1, 2001     https://doi.org/10.3892/ijo.19.6.1243
  • Pages: 1243-1247
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The oxygen deficiency seen in solid tumors is predominantly caused by an insufficient O2 supply as a result of inadequate tumor perfusion. The aim of this study was to analyze whether a number of vasodilator drugs might be suitable to increase tumor perfusion and consequently improve the oxygenation status of experimental tumors. Rats with s.c. DS-sarcomas were treated with either Na+-nitroprusside (7-25 μg·min-1·kg-1 BW) or nifedipine (10 μg·min-1·kg-1 BW). Red blood cell (RBC) flux was assessed continuously using laser-Doppler flowmetry and mean tumor pO2 was measured polarographically using O2-sensitive catheter electrodes. Systemic application of the vasodilator drugs resulted in a dose-dependent decrease in MABP. In parallel, tumor perfusion was reduced linearly with falling MABP resulting in a decrease in RBC flux by approximately 40%. Resistance to flow did not change during the infusion indicating that these drugs have no impact on tumor vessel diameter. With decreasing tumor perfusion, tumor pO2 was reduced parallel to the MABP drop. This effect was more distinct with Na+-nitroprusside than with nifedipine due to the more pronounced fall in MABP. The vasodilator drugs studied are not suitable for dilation of tumor vessels either because the tumor vasculature lacks contractile wall elements or because the vessels are already maximally dilated.

Related Articles

Journal Cover

December 2001
Volume 19 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Thews O, Kelleher DK and Vaupel P: No improvement in perfusion and oxygenation of experimental tumors upon application of vasodilator drugs. Int J Oncol 19: 1243-1247, 2001
APA
Thews, O., Kelleher, D.K., & Vaupel, P. (2001). No improvement in perfusion and oxygenation of experimental tumors upon application of vasodilator drugs. International Journal of Oncology, 19, 1243-1247. https://doi.org/10.3892/ijo.19.6.1243
MLA
Thews, O., Kelleher, D. K., Vaupel, P."No improvement in perfusion and oxygenation of experimental tumors upon application of vasodilator drugs". International Journal of Oncology 19.6 (2001): 1243-1247.
Chicago
Thews, O., Kelleher, D. K., Vaupel, P."No improvement in perfusion and oxygenation of experimental tumors upon application of vasodilator drugs". International Journal of Oncology 19, no. 6 (2001): 1243-1247. https://doi.org/10.3892/ijo.19.6.1243