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REGULATION OF BASOPHILIC AND ERYTHROID-DIFFERENTIATION OF A HUMAN CHRONIC MYELOGENOUS LEUKEMIA-CELL LINE, KU812F, BY INTERLEUKIN-3 AND STEM-CELL FACTOR

  • Authors:
    • H KITAYAMA
    • Y KANAKURA
    • T FURITSU
    • H IKEDA
    • S HIROTA
    • H SUGAHARA
    • A YAMATODANI
    • Y KANAYAMA
    • Y KITAMURA
    • Y MATSUZAWA

  • View Affiliations

  • Published online on: February 1, 1993     https://doi.org/10.3892/ijo.2.2.213
  • Pages: 213-219
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Abstract

We have investigated the effects of c-kit ligand (stem cell factor [SCF]) and interleukin-3 (IL-3) on proliferation and differentiation of a human chronic myelogenous leukemia cell line, KU812F, which can differentiate toward erythroid and basophilic lineages. When purified c-kit-positive cells (approximately 20% of KU812F cells) were used as a target, SCF induced not only proliferation but also augumented erythroid differentiation of the cells, while IL-3 did promote basophilic differentiation. Further, analyses of in situ hybridization and cell sorting with anti-c-kit antibody showed that the expression of c-kit decreased along with differentiation from immature to mature basophils and erythroid cells.

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February 1993
Volume 2 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • CiteScore: 11.4
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  • Source Normalized Impact per Paper (SNIP): 1.125
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Spandidos Publications style
KITAYAMA H, KANAKURA Y, FURITSU T, IKEDA H, HIROTA S, SUGAHARA H, YAMATODANI A, KANAYAMA Y, KITAMURA Y, MATSUZAWA Y, MATSUZAWA Y, et al: REGULATION OF BASOPHILIC AND ERYTHROID-DIFFERENTIATION OF A HUMAN CHRONIC MYELOGENOUS LEUKEMIA-CELL LINE, KU812F, BY INTERLEUKIN-3 AND STEM-CELL FACTOR. Int J Oncol 2: 213-219, 1993
APA
KITAYAMA, H., KANAKURA, Y., FURITSU, T., IKEDA, H., HIROTA, S., SUGAHARA, H. ... MATSUZAWA, Y. (1993). REGULATION OF BASOPHILIC AND ERYTHROID-DIFFERENTIATION OF A HUMAN CHRONIC MYELOGENOUS LEUKEMIA-CELL LINE, KU812F, BY INTERLEUKIN-3 AND STEM-CELL FACTOR. International Journal of Oncology, 2, 213-219. https://doi.org/10.3892/ijo.2.2.213
MLA
KITAYAMA, H., KANAKURA, Y., FURITSU, T., IKEDA, H., HIROTA, S., SUGAHARA, H., YAMATODANI, A., KANAYAMA, Y., KITAMURA, Y., MATSUZAWA, Y."REGULATION OF BASOPHILIC AND ERYTHROID-DIFFERENTIATION OF A HUMAN CHRONIC MYELOGENOUS LEUKEMIA-CELL LINE, KU812F, BY INTERLEUKIN-3 AND STEM-CELL FACTOR". International Journal of Oncology 2.2 (1993): 213-219.
Chicago
KITAYAMA, H., KANAKURA, Y., FURITSU, T., IKEDA, H., HIROTA, S., SUGAHARA, H., YAMATODANI, A., KANAYAMA, Y., KITAMURA, Y., MATSUZAWA, Y."REGULATION OF BASOPHILIC AND ERYTHROID-DIFFERENTIATION OF A HUMAN CHRONIC MYELOGENOUS LEUKEMIA-CELL LINE, KU812F, BY INTERLEUKIN-3 AND STEM-CELL FACTOR". International Journal of Oncology 2, no. 2 (1993): 213-219. https://doi.org/10.3892/ijo.2.2.213