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A NOVEL SMALL-CELL LUNG CARCINOMA-SPECIFIC DNA-BINDING ACTIVITY RELATED TO THE TRANSCRIPTION FACTOR AP-1

  • Authors:
    • J ADAMKIEWICZ
    • M BEHN
    • S BRUSSELBACH
    • K HAVEMANN
    • R MULLER

  • View Affiliations

  • Published online on: April 1, 1993     https://doi.org/10.3892/ijo.2.4.503
  • Pages: 503-512
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Abstract

A novel TRE-binding protein complex was detected specifically in 12 out of 13 small cell lung carcinoma (SCLC) cell lines. This complex was characterised by a lower electrophoretic mobility than the 'ubiquitous' complex present in all other carcinoma cell lines analysed. As shown by UV-crosslinking and South-Western blotting, the SCLC-specific complex contains a protein with an apparent M(r) > 100 kD, which is far bigger than all Fos and Jun proteins described to date. In addition, the DNA-binding specificity of this complex is different from the specificity of the 'ubiquitous' complex or a Fos/Jun heterodimer.

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April 1993
Volume 2 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 5.2
  • Ranked Oncology
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  • CiteScore: 11.4
  • CiteScore Rank: Q1: #40/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 1.125
  • SCImago Journal Rank (SJR): 1.105
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Spandidos Publications style
ADAMKIEWICZ J, BEHN M, BRUSSELBACH S, HAVEMANN K and MULLER R: A NOVEL SMALL-CELL LUNG CARCINOMA-SPECIFIC DNA-BINDING ACTIVITY RELATED TO THE TRANSCRIPTION FACTOR AP-1. Int J Oncol 2: 503-512, 1993
APA
ADAMKIEWICZ, J., BEHN, M., BRUSSELBACH, S., HAVEMANN, K., & MULLER, R. (1993). A NOVEL SMALL-CELL LUNG CARCINOMA-SPECIFIC DNA-BINDING ACTIVITY RELATED TO THE TRANSCRIPTION FACTOR AP-1. International Journal of Oncology, 2, 503-512. https://doi.org/10.3892/ijo.2.4.503
MLA
ADAMKIEWICZ, J., BEHN, M., BRUSSELBACH, S., HAVEMANN, K., MULLER, R."A NOVEL SMALL-CELL LUNG CARCINOMA-SPECIFIC DNA-BINDING ACTIVITY RELATED TO THE TRANSCRIPTION FACTOR AP-1". International Journal of Oncology 2.4 (1993): 503-512.
Chicago
ADAMKIEWICZ, J., BEHN, M., BRUSSELBACH, S., HAVEMANN, K., MULLER, R."A NOVEL SMALL-CELL LUNG CARCINOMA-SPECIFIC DNA-BINDING ACTIVITY RELATED TO THE TRANSCRIPTION FACTOR AP-1". International Journal of Oncology 2, no. 4 (1993): 503-512. https://doi.org/10.3892/ijo.2.4.503