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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 1993 Volume 2 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 1993 Volume 2 Issue 5

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Article

EXPRESSION OF THE HUMAN FETAL BAC H19 GENE IN INVASIVE CANCERS

  • Authors:
    • S DOUCRASY
    • J COLL
    • M BARROIS
    • A JOUBEL
    • S PROST
    • C DOZIER
    • D STEHELIN
    • G RIOU

  • View Affiliations / Copyright

    Affiliations: INST GUSTAVE ROUSSY,PHARMACOL CLIN & MOLEC LAB,39 RUE CAMILLE DESMOULINS,F-94805 VILLEJUIF,FRANCE. INST PASTEUR,CNRS,URA 1160,F-59019 LILLE,FRANCE.
  • Pages: 753-758
    |
    Published online on: May 1, 1993
       https://doi.org/10.3892/ijo.2.5.753
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Abstract

We have isolated a new -ene, named BAC, which is the human equivalent of the murine H19 gene and is highly expressed in most fetal tissues and in a variety of fresh tumors. BAC was analyzed in 130 untreated invasive carcinomas of different types. The frequency of BAC-expressing cancers as well as the level of expression greatly varied among the different types of cancer and within the same type of cancer. For example, the 2.3 kb BAC transcript band was detected in 94% of breast adenocarcinomas and in only 35% of epidermoid lung carcinomas with differences of 100-fold in the level of expression between tumor specimens. The majority of tumor tissues displayed BAC expression while their normal counterpart did not with the exception of normal breast tissues which contained low but significant level of BAC transcript. It is possible that BAC expression was influenced by the presence of gene deletions in tumors. Indeed, this gene is located in chromosome 11p15, a region in which deletions have frequently been observed in human cancers. Therefore, the variable levels of expression could have a biological significance and be used as a marker of tumor progression.

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Copy and paste a formatted citation
Spandidos Publications style
DOUCRASY S, COLL J, BARROIS M, JOUBEL A, PROST S, DOZIER C, STEHELIN D and RIOU G: EXPRESSION OF THE HUMAN FETAL BAC H19 GENE IN INVASIVE CANCERS. Int J Oncol 2: 753-758, 1993.
APA
DOUCRASY, S., COLL, J., BARROIS, M., JOUBEL, A., PROST, S., DOZIER, C. ... RIOU, G. (1993). EXPRESSION OF THE HUMAN FETAL BAC H19 GENE IN INVASIVE CANCERS. International Journal of Oncology, 2, 753-758. https://doi.org/10.3892/ijo.2.5.753
MLA
DOUCRASY, S., COLL, J., BARROIS, M., JOUBEL, A., PROST, S., DOZIER, C., STEHELIN, D., RIOU, G."EXPRESSION OF THE HUMAN FETAL BAC H19 GENE IN INVASIVE CANCERS". International Journal of Oncology 2.5 (1993): 753-758.
Chicago
DOUCRASY, S., COLL, J., BARROIS, M., JOUBEL, A., PROST, S., DOZIER, C., STEHELIN, D., RIOU, G."EXPRESSION OF THE HUMAN FETAL BAC H19 GENE IN INVASIVE CANCERS". International Journal of Oncology 2, no. 5 (1993): 753-758. https://doi.org/10.3892/ijo.2.5.753
Copy and paste a formatted citation
x
Spandidos Publications style
DOUCRASY S, COLL J, BARROIS M, JOUBEL A, PROST S, DOZIER C, STEHELIN D and RIOU G: EXPRESSION OF THE HUMAN FETAL BAC H19 GENE IN INVASIVE CANCERS. Int J Oncol 2: 753-758, 1993.
APA
DOUCRASY, S., COLL, J., BARROIS, M., JOUBEL, A., PROST, S., DOZIER, C. ... RIOU, G. (1993). EXPRESSION OF THE HUMAN FETAL BAC H19 GENE IN INVASIVE CANCERS. International Journal of Oncology, 2, 753-758. https://doi.org/10.3892/ijo.2.5.753
MLA
DOUCRASY, S., COLL, J., BARROIS, M., JOUBEL, A., PROST, S., DOZIER, C., STEHELIN, D., RIOU, G."EXPRESSION OF THE HUMAN FETAL BAC H19 GENE IN INVASIVE CANCERS". International Journal of Oncology 2.5 (1993): 753-758.
Chicago
DOUCRASY, S., COLL, J., BARROIS, M., JOUBEL, A., PROST, S., DOZIER, C., STEHELIN, D., RIOU, G."EXPRESSION OF THE HUMAN FETAL BAC H19 GENE IN INVASIVE CANCERS". International Journal of Oncology 2, no. 5 (1993): 753-758. https://doi.org/10.3892/ijo.2.5.753
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