COMBINED INTERLEUKIN-2 AND OKT3 THERAPY IN THE TREATMENT OF METASTATIC MELANOMA

  • Authors:
    • J HOLLINGWORTH
    • T HORSBURGH
    • PS VEITCH
    • PRF BELL
    • S KHANNA
  • View Affiliations

  • Published online on: May 1, 1993     https://doi.org/10.3892/ijo.2.5.847
  • Pages: 847-850
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Objective tumour responses have been documented in patients with malignant melanoma following therapy with recombinant interleukin-2 (rIL-2). Recent attempts to reduce toxicity and retain therapeutic efficacy of rIL-2 have involved low-dose subcutaneous rIL-2 administration and the exploration of synergy with other agents. The anti-CD3 monoclonal antibody OKT3 (Cilag), is immunosuppressive when given at high doses. However, at low doses anti-CD3 mAb are vigorously immunostimulatory in vitro and have been associated with tumour regression in animal models. We have explored the immunomodulatory properties and toxicity of combining intravenous OKT3 with subcutaneous low-dose rIL-2 in a patient with malignant melanoma.

Related Articles

Journal Cover

May 1993
Volume 2 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
HOLLINGWORTH J, HORSBURGH T, VEITCH P, BELL P and KHANNA S: COMBINED INTERLEUKIN-2 AND OKT3 THERAPY IN THE TREATMENT OF METASTATIC MELANOMA. Int J Oncol 2: 847-850, 1993
APA
HOLLINGWORTH, J., HORSBURGH, T., VEITCH, P., BELL, P., & KHANNA, S. (1993). COMBINED INTERLEUKIN-2 AND OKT3 THERAPY IN THE TREATMENT OF METASTATIC MELANOMA. International Journal of Oncology, 2, 847-850. https://doi.org/10.3892/ijo.2.5.847
MLA
HOLLINGWORTH, J., HORSBURGH, T., VEITCH, P., BELL, P., KHANNA, S."COMBINED INTERLEUKIN-2 AND OKT3 THERAPY IN THE TREATMENT OF METASTATIC MELANOMA". International Journal of Oncology 2.5 (1993): 847-850.
Chicago
HOLLINGWORTH, J., HORSBURGH, T., VEITCH, P., BELL, P., KHANNA, S."COMBINED INTERLEUKIN-2 AND OKT3 THERAPY IN THE TREATMENT OF METASTATIC MELANOMA". International Journal of Oncology 2, no. 5 (1993): 847-850. https://doi.org/10.3892/ijo.2.5.847