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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 1993 Volume 2 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June 1993 Volume 2 Issue 6

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Article

REGULATION OF MATRIX METALLOPROTEINASES - THEIR ROLE IN TUMOR INVASION AND METASTASIS

  • Authors:
    • DW COTTAM
    • RC REES

  • View Affiliations / Copyright

    Affiliations: UNIV SHEFFIELD, SCH MED, FAC CANC STUDIES, SHEFFIELD S10 2RX, S YORKSHIRE, ENGLAND. NCI, DIV CANC ETIOL, BETHESDA, MD 20892 USA.
  • Pages: 861-872
    |
    Published online on: June 1, 1993
       https://doi.org/10.3892/ijo.2.6.861
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Abstract

In order for tumor cells to colonise secondary organs and tissues it is necessary for them to be able to complete all the essential steps of the metastatic cascade. We discuss here some of the important aspects of this process, highlighting those events likely to be important in the control of tumor cell invasion. The expression of matrix metalloproteinases (MMP) capable of degrading tissue matrix or basement membranes, constitutes an important feature of tumor cell escape from the primary neoplasm and entry into/ colonisation of the secondary body site. In particular, the balance between MMP and protease inhibitor expression will determine the invasive capacity of a cancer cell. The molecular control of gene expression, together with the molecules important in regulating the production of proteinases and their inhibitors is complex, and the important facets of these pathways are discussed. Cytokines, particularly tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1) and transforming growth factor-beta (TGF-beta), play a crucial role in modulating MMP-2 and MMP-9 expression, and these, together with other regulatory cytokines constitute an important mechanism whereby the tumor cells can increase their invasive potential through the secretion of proteases.

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Copy and paste a formatted citation
Spandidos Publications style
COTTAM D and REES R: REGULATION OF MATRIX METALLOPROTEINASES - THEIR ROLE IN TUMOR INVASION AND METASTASIS. Int J Oncol 2: 861-872, 1993.
APA
COTTAM, D., & REES, R. (1993). REGULATION OF MATRIX METALLOPROTEINASES - THEIR ROLE IN TUMOR INVASION AND METASTASIS. International Journal of Oncology, 2, 861-872. https://doi.org/10.3892/ijo.2.6.861
MLA
COTTAM, D., REES, R."REGULATION OF MATRIX METALLOPROTEINASES - THEIR ROLE IN TUMOR INVASION AND METASTASIS". International Journal of Oncology 2.6 (1993): 861-872.
Chicago
COTTAM, D., REES, R."REGULATION OF MATRIX METALLOPROTEINASES - THEIR ROLE IN TUMOR INVASION AND METASTASIS". International Journal of Oncology 2, no. 6 (1993): 861-872. https://doi.org/10.3892/ijo.2.6.861
Copy and paste a formatted citation
x
Spandidos Publications style
COTTAM D and REES R: REGULATION OF MATRIX METALLOPROTEINASES - THEIR ROLE IN TUMOR INVASION AND METASTASIS. Int J Oncol 2: 861-872, 1993.
APA
COTTAM, D., & REES, R. (1993). REGULATION OF MATRIX METALLOPROTEINASES - THEIR ROLE IN TUMOR INVASION AND METASTASIS. International Journal of Oncology, 2, 861-872. https://doi.org/10.3892/ijo.2.6.861
MLA
COTTAM, D., REES, R."REGULATION OF MATRIX METALLOPROTEINASES - THEIR ROLE IN TUMOR INVASION AND METASTASIS". International Journal of Oncology 2.6 (1993): 861-872.
Chicago
COTTAM, D., REES, R."REGULATION OF MATRIX METALLOPROTEINASES - THEIR ROLE IN TUMOR INVASION AND METASTASIS". International Journal of Oncology 2, no. 6 (1993): 861-872. https://doi.org/10.3892/ijo.2.6.861
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