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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 1993 Volume 2 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June 1993 Volume 2 Issue 6

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Article

SECRETION AND BINDING OF INSULIN-LIKE GROWTH FACTOR-I BY A HUMAN MEDULLARY-THYROID CARCINOMA CELL-LINE

  • Authors:
    • CR BETHEL
    • HF SAADI
    • WM HOUT
    • JC VITULLO
    • DC ARON

  • View Affiliations / Copyright

    Affiliations: VET ADM MED CTR,DEPT MED,DIV ENDOCRINOL & HYPERTENS,MED SERV 111W,10701 E BLVD,CLEVELAND,OH 44106. CASE WESTERN RESERVE UNIV,SCH MED,CLEVELAND,OH 44106.
  • Pages: 961-967
    |
    Published online on: June 1, 1993
       https://doi.org/10.3892/ijo.2.6.961
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Abstract

The TT human medullary thyroid carcinoma cell line secretes a 7.5 kD species with insulin-like growth factor (IGF-I) immunoreactivity and HPLC mobility and expresses IGF-I mRNA. Conditioned medium also contained IGF-binding activity with a pattern of displacement of [I-125]-IGF-I characteristic of IGF binding proteins. Western ligand analysis and immunobloting with anti-IGFBP4 antiserum identified a 34 kD IGF-I binding species. Northern analysis identified a 2.1 kb IGFBP4 mRNA species. Cell surface binding of [I-125]-IGF-I identified Type I IGF receptors. TT cells constitute a useful model to study the IGF-I autocrine system in the transformed state.

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Copy and paste a formatted citation
Spandidos Publications style
BETHEL C, SAADI H, HOUT W, VITULLO J and ARON D: SECRETION AND BINDING OF INSULIN-LIKE GROWTH FACTOR-I BY A HUMAN MEDULLARY-THYROID CARCINOMA CELL-LINE. Int J Oncol 2: 961-967, 1993.
APA
BETHEL, C., SAADI, H., HOUT, W., VITULLO, J., & ARON, D. (1993). SECRETION AND BINDING OF INSULIN-LIKE GROWTH FACTOR-I BY A HUMAN MEDULLARY-THYROID CARCINOMA CELL-LINE. International Journal of Oncology, 2, 961-967. https://doi.org/10.3892/ijo.2.6.961
MLA
BETHEL, C., SAADI, H., HOUT, W., VITULLO, J., ARON, D."SECRETION AND BINDING OF INSULIN-LIKE GROWTH FACTOR-I BY A HUMAN MEDULLARY-THYROID CARCINOMA CELL-LINE". International Journal of Oncology 2.6 (1993): 961-967.
Chicago
BETHEL, C., SAADI, H., HOUT, W., VITULLO, J., ARON, D."SECRETION AND BINDING OF INSULIN-LIKE GROWTH FACTOR-I BY A HUMAN MEDULLARY-THYROID CARCINOMA CELL-LINE". International Journal of Oncology 2, no. 6 (1993): 961-967. https://doi.org/10.3892/ijo.2.6.961
Copy and paste a formatted citation
x
Spandidos Publications style
BETHEL C, SAADI H, HOUT W, VITULLO J and ARON D: SECRETION AND BINDING OF INSULIN-LIKE GROWTH FACTOR-I BY A HUMAN MEDULLARY-THYROID CARCINOMA CELL-LINE. Int J Oncol 2: 961-967, 1993.
APA
BETHEL, C., SAADI, H., HOUT, W., VITULLO, J., & ARON, D. (1993). SECRETION AND BINDING OF INSULIN-LIKE GROWTH FACTOR-I BY A HUMAN MEDULLARY-THYROID CARCINOMA CELL-LINE. International Journal of Oncology, 2, 961-967. https://doi.org/10.3892/ijo.2.6.961
MLA
BETHEL, C., SAADI, H., HOUT, W., VITULLO, J., ARON, D."SECRETION AND BINDING OF INSULIN-LIKE GROWTH FACTOR-I BY A HUMAN MEDULLARY-THYROID CARCINOMA CELL-LINE". International Journal of Oncology 2.6 (1993): 961-967.
Chicago
BETHEL, C., SAADI, H., HOUT, W., VITULLO, J., ARON, D."SECRETION AND BINDING OF INSULIN-LIKE GROWTH FACTOR-I BY A HUMAN MEDULLARY-THYROID CARCINOMA CELL-LINE". International Journal of Oncology 2, no. 6 (1993): 961-967. https://doi.org/10.3892/ijo.2.6.961
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