GROWTH-INHIBITION AND CHANGE IN MORPHOLOGY AND MOTILITY OF SCLC CELL-LINES BY HEPATOCYTE GROWTH-FACTOR SCATTER FACTOR

  • Authors:
    • K RYGAARD
    • B KLAUSEN
    • T NAKAMURA
    • M SPANGTHOMSEN
  • View Affiliations

  • Published online on: June 1, 1993     https://doi.org/10.3892/ijo.2.6.991
  • Pages: 991-996
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Abstract

Expression of the c-met proto-oncogene is common iii small cell lung cancer (SCLC) cell lines. The product of this proto-oncogene is the receptor for hepatocyte growth factor (HGF), also known as scatter factor (SF) and hepatopoietin A. We examined the effect of HGF/SF on 8 SCLC cell lines of which six expressed c-Met and 2 control cell lines did not. The effect was monitored by growth curves, in vitro migration in Boyden chambers. and by examination of morphology. Three cell lines responded in one or more of the following ways: Growth inhibition, morphological alterations. and increased migration in Boyden chambers. We conclude that functional c-Met receptors are frequently expressed in SCLC and may contribute to the behaviour of this tumour type.

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June 1993
Volume 2 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
RYGAARD K, KLAUSEN B, NAKAMURA T and SPANGTHOMSEN M: GROWTH-INHIBITION AND CHANGE IN MORPHOLOGY AND MOTILITY OF SCLC CELL-LINES BY HEPATOCYTE GROWTH-FACTOR SCATTER FACTOR. Int J Oncol 2: 991-996, 1993
APA
RYGAARD, K., KLAUSEN, B., NAKAMURA, T., & SPANGTHOMSEN, M. (1993). GROWTH-INHIBITION AND CHANGE IN MORPHOLOGY AND MOTILITY OF SCLC CELL-LINES BY HEPATOCYTE GROWTH-FACTOR SCATTER FACTOR. International Journal of Oncology, 2, 991-996. https://doi.org/10.3892/ijo.2.6.991
MLA
RYGAARD, K., KLAUSEN, B., NAKAMURA, T., SPANGTHOMSEN, M."GROWTH-INHIBITION AND CHANGE IN MORPHOLOGY AND MOTILITY OF SCLC CELL-LINES BY HEPATOCYTE GROWTH-FACTOR SCATTER FACTOR". International Journal of Oncology 2.6 (1993): 991-996.
Chicago
RYGAARD, K., KLAUSEN, B., NAKAMURA, T., SPANGTHOMSEN, M."GROWTH-INHIBITION AND CHANGE IN MORPHOLOGY AND MOTILITY OF SCLC CELL-LINES BY HEPATOCYTE GROWTH-FACTOR SCATTER FACTOR". International Journal of Oncology 2, no. 6 (1993): 991-996. https://doi.org/10.3892/ijo.2.6.991