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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 2002 Volume 20 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2002 Volume 20 Issue 1

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Article

GAS64, the first amplified and putative non-translated gene

  • Authors:
    • Ulrike Fischer
    • Nicole Schutz
    • Doris Hemmer
    • Eckart Meese

  • View Affiliations / Copyright

    Affiliations: Institut fur Humangenetik, Medical School, University of Saarland, D-66421 Homburg/Saar, Germany
  • Pages: 173-176
    |
    Published online on: January 1, 2002
       https://doi.org/10.3892/ijo.20.1.173
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Abstract

Gene amplification occurs frequently in human glioblastomas. We report the amplification and expression analysis of glioma amplified sequence 64 (GAS64) which was recently identified by microdissection mediated cDNA capture from the amplicon at 12q13-15. Herein we analyzed primary tumor tissues for amplification frequency and found amplification of GAS64 in 5 out of 49 glioblastomas. The amplification frequency of 10% for GAS64 found among glioblastomas is comparable to the frequency described for other genes from the 12q13-15 amplicon. To isolate the full-length cDNA of GAS64, we performed cDNA library screening and RACE. Sequence analysis of the gene revealed no open reading frame longer than 191 bp suggesting that the RNA may function as a non-translated RNA. Non-translated RNAs have been reported to function on the RNA level as regulators of gene expression. Northern hybridization of GAS64 revealed an increased GAS64 expression in many human glioblastomas with and without GAS64 gene amplification. This is the first report on an amplified and expressed gene with a short open reading frame (ORF). GAS64 may be a candidate gene for regulating gene expression in glioblastomas at the RNA level, possibly through expression of a non-translated RNA.

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Copy and paste a formatted citation
Spandidos Publications style
Fischer U, Schutz N, Hemmer D and Meese E: GAS64, the first amplified and putative non-translated gene. Int J Oncol 20: 173-176, 2002.
APA
Fischer, U., Schutz, N., Hemmer, D., & Meese, E. (2002). GAS64, the first amplified and putative non-translated gene. International Journal of Oncology, 20, 173-176. https://doi.org/10.3892/ijo.20.1.173
MLA
Fischer, U., Schutz, N., Hemmer, D., Meese, E."GAS64, the first amplified and putative non-translated gene". International Journal of Oncology 20.1 (2002): 173-176.
Chicago
Fischer, U., Schutz, N., Hemmer, D., Meese, E."GAS64, the first amplified and putative non-translated gene". International Journal of Oncology 20, no. 1 (2002): 173-176. https://doi.org/10.3892/ijo.20.1.173
Copy and paste a formatted citation
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Spandidos Publications style
Fischer U, Schutz N, Hemmer D and Meese E: GAS64, the first amplified and putative non-translated gene. Int J Oncol 20: 173-176, 2002.
APA
Fischer, U., Schutz, N., Hemmer, D., & Meese, E. (2002). GAS64, the first amplified and putative non-translated gene. International Journal of Oncology, 20, 173-176. https://doi.org/10.3892/ijo.20.1.173
MLA
Fischer, U., Schutz, N., Hemmer, D., Meese, E."GAS64, the first amplified and putative non-translated gene". International Journal of Oncology 20.1 (2002): 173-176.
Chicago
Fischer, U., Schutz, N., Hemmer, D., Meese, E."GAS64, the first amplified and putative non-translated gene". International Journal of Oncology 20, no. 1 (2002): 173-176. https://doi.org/10.3892/ijo.20.1.173
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