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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 2002 Volume 20 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2002 Volume 20 Issue 3

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Article

The effect of adjuvant 5'-deoxy-5-fluorouridine in early stage breast cancer patients: Results from a multicenter randomized controlled trial

  • Authors:
    • Takeshi Tominaga
    • Masakazu Toi
    • Osahiko Abe
    • Yasuo Ohashi
    • Junichi Uchino
    • Hiroshi Hayasaka
    • Rikiya Abe
    • Masaru Izuo
    • Kohji Enomoto
    • Hiromu Watanabe
    • Minoru Yoshida
    • Tetsuo Taguchi
    • Hiroki Koyama
    • Tsuneaki Senoo
    • Tetsuya Toge
    • Yasumasa Monden
    • Takao Hattori
    • Yasuo Nomura
    • Keizo Sugimachi
    • Koichi Hirata
    • Hiroaki Nakazato
    • Shigeto Miura
    • Tadaoki Morimoto
    • Kazuaki Asaishi
    • Izo Kimijima
    • Jun Ota
    • Hiroshi Sonoo
    • Susumu Yamaguchi
  • View Affiliations / Copyright

    Affiliations: Breast Cancer Center, Toyosu Hospital, Showa University School of Medicine, Tokyo 135-8577, Japan. t-tominaga@hkg.odn.ne.jp
  • Pages: 517-525
    |
    Published online on: March 1, 2002
       https://doi.org/10.3892/ijo.20.3.517
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Abstract

To assess the efficacy of 5'-DFUR, an intermediate of capecitabine, for adjuvant treatment of early breast cancer, we conducted an open-labeled multi-center randomized controlled trial to compare postoperative 5'-DFUR treatment with surgery alone. We enrolled 1217 primary breast cancer patients and randomly assigned them into two treatment groups; one received six-month postoperative 5'-DFUR treatment by consecutive or intermittent administration, and the other surgery alone. Follow-up surveys were conducted once a year for all subjects simultaneously and examined their outcome/presence or absence of the cancer recurrence. The central study committee reviewed all follow-up data and judged the recurrence data to be used for the analysis. Eight-year follow-up data showed no significant differences in relapse-free and overall survival between the two groups, and 5'-DFUR treatment regimen showed an extremely high tolerance. Possible explanations are discussed for the finding of no significant survival difference between adjuvant 6-month 5'-DFUR monotherapy and surgery alone in early breast cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Tominaga T, Toi M, Abe O, Ohashi Y, Uchino J, Hayasaka H, Abe R, Izuo M, Enomoto K, Watanabe H, Watanabe H, et al: The effect of adjuvant 5'-deoxy-5-fluorouridine in early stage breast cancer patients: Results from a multicenter randomized controlled trial. Int J Oncol 20: 517-525, 2002.
APA
Tominaga, T., Toi, M., Abe, O., Ohashi, Y., Uchino, J., Hayasaka, H. ... Yamaguchi, S. (2002). The effect of adjuvant 5'-deoxy-5-fluorouridine in early stage breast cancer patients: Results from a multicenter randomized controlled trial. International Journal of Oncology, 20, 517-525. https://doi.org/10.3892/ijo.20.3.517
MLA
Tominaga, T., Toi, M., Abe, O., Ohashi, Y., Uchino, J., Hayasaka, H., Abe, R., Izuo, M., Enomoto, K., Watanabe, H., Yoshida, M., Taguchi, T., Koyama, H., Senoo, T., Toge, T., Monden, Y., Hattori, T., Nomura, Y., Sugimachi, K., Hirata, K., Nakazato, H., Miura, S., Morimoto, T., Asaishi, K., Kimijima, I., Ota, J., Sonoo, H., Yamaguchi, S."The effect of adjuvant 5'-deoxy-5-fluorouridine in early stage breast cancer patients: Results from a multicenter randomized controlled trial". International Journal of Oncology 20.3 (2002): 517-525.
Chicago
Tominaga, T., Toi, M., Abe, O., Ohashi, Y., Uchino, J., Hayasaka, H., Abe, R., Izuo, M., Enomoto, K., Watanabe, H., Yoshida, M., Taguchi, T., Koyama, H., Senoo, T., Toge, T., Monden, Y., Hattori, T., Nomura, Y., Sugimachi, K., Hirata, K., Nakazato, H., Miura, S., Morimoto, T., Asaishi, K., Kimijima, I., Ota, J., Sonoo, H., Yamaguchi, S."The effect of adjuvant 5'-deoxy-5-fluorouridine in early stage breast cancer patients: Results from a multicenter randomized controlled trial". International Journal of Oncology 20, no. 3 (2002): 517-525. https://doi.org/10.3892/ijo.20.3.517
Copy and paste a formatted citation
x
Spandidos Publications style
Tominaga T, Toi M, Abe O, Ohashi Y, Uchino J, Hayasaka H, Abe R, Izuo M, Enomoto K, Watanabe H, Watanabe H, et al: The effect of adjuvant 5'-deoxy-5-fluorouridine in early stage breast cancer patients: Results from a multicenter randomized controlled trial. Int J Oncol 20: 517-525, 2002.
APA
Tominaga, T., Toi, M., Abe, O., Ohashi, Y., Uchino, J., Hayasaka, H. ... Yamaguchi, S. (2002). The effect of adjuvant 5'-deoxy-5-fluorouridine in early stage breast cancer patients: Results from a multicenter randomized controlled trial. International Journal of Oncology, 20, 517-525. https://doi.org/10.3892/ijo.20.3.517
MLA
Tominaga, T., Toi, M., Abe, O., Ohashi, Y., Uchino, J., Hayasaka, H., Abe, R., Izuo, M., Enomoto, K., Watanabe, H., Yoshida, M., Taguchi, T., Koyama, H., Senoo, T., Toge, T., Monden, Y., Hattori, T., Nomura, Y., Sugimachi, K., Hirata, K., Nakazato, H., Miura, S., Morimoto, T., Asaishi, K., Kimijima, I., Ota, J., Sonoo, H., Yamaguchi, S."The effect of adjuvant 5'-deoxy-5-fluorouridine in early stage breast cancer patients: Results from a multicenter randomized controlled trial". International Journal of Oncology 20.3 (2002): 517-525.
Chicago
Tominaga, T., Toi, M., Abe, O., Ohashi, Y., Uchino, J., Hayasaka, H., Abe, R., Izuo, M., Enomoto, K., Watanabe, H., Yoshida, M., Taguchi, T., Koyama, H., Senoo, T., Toge, T., Monden, Y., Hattori, T., Nomura, Y., Sugimachi, K., Hirata, K., Nakazato, H., Miura, S., Morimoto, T., Asaishi, K., Kimijima, I., Ota, J., Sonoo, H., Yamaguchi, S."The effect of adjuvant 5'-deoxy-5-fluorouridine in early stage breast cancer patients: Results from a multicenter randomized controlled trial". International Journal of Oncology 20, no. 3 (2002): 517-525. https://doi.org/10.3892/ijo.20.3.517
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