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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 2002 Volume 20 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2002 Volume 20 Issue 3

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Article

The induction of apoptosis by a combined 1,25(OH)2D3 analog, EB1089 and TGF-β1 in NCI-H929 multiple myeloma cells

  • Authors:
    • Woo Hyun Park
    • Jae Goo Seol
    • Eun Shil Kim
    • Lise Binderup
    • H. Phillip Koeffler
    • Byoung Kook Kim
    • Young Yiul Lee

  • View Affiliations / Copyright

    Affiliations: Cancer Research Institute and Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea
  • Pages: 533-542
    |
    Published online on: March 1, 2002
       https://doi.org/10.3892/ijo.20.3.533
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Abstract

Previously, we reported that EB1089 inhibited the growth of NCI-H929 myeloma cells via cell cycle arrest and apoptosis. In the present study, we investigated whether a combined EB1089 and TGF-β1 synergistically inhibited the cell proliferation of myeloma cell lines. While TGF-β1 alone could not inhibit the proliferation of any of the tested myeloma cells, synergistic effect between EB1089 (1x10-8 M) and TGF-β1 (1 ng/ml) was observed in NCI-H929 cells. TGF-β1 intensified the decreased expression of CDK2, CDK4, CDK6 and cyclin D1 in EB1089-treated NCI-H929 cells. However, these effects did not intensify to decrease CDK2 activity of EB1089-treated NCI-H929 cells, resulting in no difference in the extent of G1 arrest between EB1089- and both agents-treated cells. Remarkably, both agents synergistically induce apoptosis of NCI-H929 cells, which was accompanied with up-regulation of Bax, degradation of PARP and Rb proteins, and loss of mitochondrial transmembrane potential (Δψm). EB1089 caused the induction of SMAD4, a mediator of TGF-β1 signaling. In addition, a combined EB1089 and TGF-β1 increased p21 and JNK/SAPK activity whereas neither EB1089 nor TGF-β1 affected p21 and JNK/SAPK activity. Taken together, these results suggest that treatment with both EB1089 and TGF-β1 synergistically inhibits the proliferation of NCI-H929 cells through apoptosis.

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Copy and paste a formatted citation
Spandidos Publications style
Park WH, Seol JG, Kim ES, Binderup L, Koeffler HP, Kim BK and Lee YY: The induction of apoptosis by a combined 1,25(OH)2D3 analog, EB1089 and TGF-β1 in NCI-H929 multiple myeloma cells. Int J Oncol 20: 533-542, 2002.
APA
Park, W.H., Seol, J.G., Kim, E.S., Binderup, L., Koeffler, H.P., Kim, B.K., & Lee, Y.Y. (2002). The induction of apoptosis by a combined 1,25(OH)2D3 analog, EB1089 and TGF-β1 in NCI-H929 multiple myeloma cells. International Journal of Oncology, 20, 533-542. https://doi.org/10.3892/ijo.20.3.533
MLA
Park, W. H., Seol, J. G., Kim, E. S., Binderup, L., Koeffler, H. P., Kim, B. K., Lee, Y. Y."The induction of apoptosis by a combined 1,25(OH)2D3 analog, EB1089 and TGF-β1 in NCI-H929 multiple myeloma cells". International Journal of Oncology 20.3 (2002): 533-542.
Chicago
Park, W. H., Seol, J. G., Kim, E. S., Binderup, L., Koeffler, H. P., Kim, B. K., Lee, Y. Y."The induction of apoptosis by a combined 1,25(OH)2D3 analog, EB1089 and TGF-β1 in NCI-H929 multiple myeloma cells". International Journal of Oncology 20, no. 3 (2002): 533-542. https://doi.org/10.3892/ijo.20.3.533
Copy and paste a formatted citation
x
Spandidos Publications style
Park WH, Seol JG, Kim ES, Binderup L, Koeffler HP, Kim BK and Lee YY: The induction of apoptosis by a combined 1,25(OH)2D3 analog, EB1089 and TGF-β1 in NCI-H929 multiple myeloma cells. Int J Oncol 20: 533-542, 2002.
APA
Park, W.H., Seol, J.G., Kim, E.S., Binderup, L., Koeffler, H.P., Kim, B.K., & Lee, Y.Y. (2002). The induction of apoptosis by a combined 1,25(OH)2D3 analog, EB1089 and TGF-β1 in NCI-H929 multiple myeloma cells. International Journal of Oncology, 20, 533-542. https://doi.org/10.3892/ijo.20.3.533
MLA
Park, W. H., Seol, J. G., Kim, E. S., Binderup, L., Koeffler, H. P., Kim, B. K., Lee, Y. Y."The induction of apoptosis by a combined 1,25(OH)2D3 analog, EB1089 and TGF-β1 in NCI-H929 multiple myeloma cells". International Journal of Oncology 20.3 (2002): 533-542.
Chicago
Park, W. H., Seol, J. G., Kim, E. S., Binderup, L., Koeffler, H. P., Kim, B. K., Lee, Y. Y."The induction of apoptosis by a combined 1,25(OH)2D3 analog, EB1089 and TGF-β1 in NCI-H929 multiple myeloma cells". International Journal of Oncology 20, no. 3 (2002): 533-542. https://doi.org/10.3892/ijo.20.3.533
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