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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 2002 Volume 20 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2002 Volume 20 Issue 3

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Article

Low sex steroid environment affects survival and steroid secretion of ovarian tumour cells in primary cultures

  • Authors:
    • M. Taube
    • T. Hockenstrom
    • M. Isaksson
    • P. R. Lindgren
    • T. Backstrom

  • View Affiliations / Copyright

    Affiliations: Department of Clinical Sciences, Obstetrics and Gynaecology, University Hospital of Umea, SE 901 85 Umea, Sweden
  • Pages: 589-594
    |
    Published online on: March 1, 2002
       https://doi.org/10.3892/ijo.20.3.589
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Abstract

Ovarian epithelial tumours are considered to be endocrine related. The effects of an environment with low levels of the steroid hormones 17 β-estradiol, testosterone or progesterone on cell survival and steroid secretion were studied in primary cell cultures derived from 25 patients suffering from epithelial ovarian tumours. Tumour cells cultured in 17 β-estradiol and testosterone showed a reduced cell survival (-10.3±2.3% and -15.6±2.7% minimum survival respectively). This reduction was inversely proportional to hormone concentrations within the range studied. No similar effect was observed in the progesterone cultures. It was found that 17 β-estradiol was secreted from the primary cell cultures and, interestingly, the amount of 17 β-estradiol secreted increased with increasing levels of 17 β-estradiol in the environment. Neither progesterone nor testosterone production was observed in any of the cultures studied. It is believed that 17 β-estradiol has an antiapoptotic effect on ovarian surface epithelial (OSE) cells. Reduction of 17 β-estradiol in the environment may inhibit this effect, resulting in reduced cell survival. The ability of ovarian epithelial tumour cells to secrete 17 β-estradiol suggests that epithelial ovarian tumours play an active role in altering their own hormonal environment, promoting tumour progression.

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Copy and paste a formatted citation
Spandidos Publications style
Taube M, Hockenstrom T, Isaksson M, Lindgren PR and Backstrom T: Low sex steroid environment affects survival and steroid secretion of ovarian tumour cells in primary cultures. Int J Oncol 20: 589-594, 2002.
APA
Taube, M., Hockenstrom, T., Isaksson, M., Lindgren, P.R., & Backstrom, T. (2002). Low sex steroid environment affects survival and steroid secretion of ovarian tumour cells in primary cultures. International Journal of Oncology, 20, 589-594. https://doi.org/10.3892/ijo.20.3.589
MLA
Taube, M., Hockenstrom, T., Isaksson, M., Lindgren, P. R., Backstrom, T."Low sex steroid environment affects survival and steroid secretion of ovarian tumour cells in primary cultures". International Journal of Oncology 20.3 (2002): 589-594.
Chicago
Taube, M., Hockenstrom, T., Isaksson, M., Lindgren, P. R., Backstrom, T."Low sex steroid environment affects survival and steroid secretion of ovarian tumour cells in primary cultures". International Journal of Oncology 20, no. 3 (2002): 589-594. https://doi.org/10.3892/ijo.20.3.589
Copy and paste a formatted citation
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Spandidos Publications style
Taube M, Hockenstrom T, Isaksson M, Lindgren PR and Backstrom T: Low sex steroid environment affects survival and steroid secretion of ovarian tumour cells in primary cultures. Int J Oncol 20: 589-594, 2002.
APA
Taube, M., Hockenstrom, T., Isaksson, M., Lindgren, P.R., & Backstrom, T. (2002). Low sex steroid environment affects survival and steroid secretion of ovarian tumour cells in primary cultures. International Journal of Oncology, 20, 589-594. https://doi.org/10.3892/ijo.20.3.589
MLA
Taube, M., Hockenstrom, T., Isaksson, M., Lindgren, P. R., Backstrom, T."Low sex steroid environment affects survival and steroid secretion of ovarian tumour cells in primary cultures". International Journal of Oncology 20.3 (2002): 589-594.
Chicago
Taube, M., Hockenstrom, T., Isaksson, M., Lindgren, P. R., Backstrom, T."Low sex steroid environment affects survival and steroid secretion of ovarian tumour cells in primary cultures". International Journal of Oncology 20, no. 3 (2002): 589-594. https://doi.org/10.3892/ijo.20.3.589
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