Expression of PLAG1 and HMGIC proteins and fusion transcripts in radiation-associated pleomorphic adenomas

  • Authors:
    • F. Enlund
    • A. Nordkvist
    • P. Sahlin
    • J. Mark
    • G. Stenman
  • View Affiliations

  • Published online on: April 1, 2002     https://doi.org/10.3892/ijo.20.4.713
  • Pages: 713-716
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Abstract

Extensive cytogenetic investigations of pleomorphic adenomas of the salivary glands have unequivocally demonstrated that they are cytogenetically monoclonal and are characterized by a high frequency of tumor specific chromosome abnormalities involving in particular chromosome bands 3p21, 8q12 and 12q14-15. Here we show that two radiation-associated and cytogenetically polyclonal adenomas without gross rearrangements of these breakpoints show simultaneous overexpression of the PLAG1 and HMGIC genes, i.e. the target genes of the 8q12 and 12q14-15 rearrangements in sporadic adenomas. In addition, one of the tumors expressed a cryptic CTNNB1-PLAG1 fusion transcript. Our findings strongly suggest that identical or very similar molecular mechanisms are operating during adenoma tumorigenesis irrespective of whether the tumors are cytogenetically polyclonal or whether they have non-random, tumor specific abnormalities. Cytogenetically polyclonal adenomas are thus most likely also of monoclonal origin.

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April 2002
Volume 20 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Enlund F, Nordkvist A, Sahlin P, Mark J and Stenman G: Expression of PLAG1 and HMGIC proteins and fusion transcripts in radiation-associated pleomorphic adenomas. Int J Oncol 20: 713-716, 2002
APA
Enlund, F., Nordkvist, A., Sahlin, P., Mark, J., & Stenman, G. (2002). Expression of PLAG1 and HMGIC proteins and fusion transcripts in radiation-associated pleomorphic adenomas. International Journal of Oncology, 20, 713-716. https://doi.org/10.3892/ijo.20.4.713
MLA
Enlund, F., Nordkvist, A., Sahlin, P., Mark, J., Stenman, G."Expression of PLAG1 and HMGIC proteins and fusion transcripts in radiation-associated pleomorphic adenomas". International Journal of Oncology 20.4 (2002): 713-716.
Chicago
Enlund, F., Nordkvist, A., Sahlin, P., Mark, J., Stenman, G."Expression of PLAG1 and HMGIC proteins and fusion transcripts in radiation-associated pleomorphic adenomas". International Journal of Oncology 20, no. 4 (2002): 713-716. https://doi.org/10.3892/ijo.20.4.713