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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2002 Volume 20 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2002 Volume 20 Issue 4

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Article

A possible role for IVIg in the treatment of soft tissue sarcoma: A clinical case and an experimental model

  • Authors:
    • Ofer Merimsky
    • Isaac Meller
    • Moshe Inbar
    • Sara Bar-Yehuda
    • Yehuda Shoenfeld
    • Pnina Fishman

  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Tel-Aviv Sourasky Medical Center, Tel-Aviv 64239, Israel. merimsky@zahav.net.il
  • Pages: 839-843
    |
    Published online on: April 1, 2002
       https://doi.org/10.3892/ijo.20.4.839
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Abstract

A patient with a malignant peripheral nerve sheath tumor (MPNST) was treated with IVIg for multiple sclerosis. Her MPNST course was remarkably longer and more indolent than expected; she achieved a disease-free interval (DFI) of 30 months. Seven other patients, who were not treated by IVIg, had a relatively aggressive course (median DFI 3 months). These results led us to examine the effect of IVIg on the growth of sarcoma in vitro and in vivo in an experimental model of MCA-bearing mice. When added to MCA-105 sarcoma cell cultures, IVIg produced a dose-dependent inhibitory effect on [3H]-thymidine incorporation. The maximal inhibitory effect was at a concentration of 50 mg/ml IVIg. Cell cycle analysis revealed a hypodiploid peak at the lower fluorescence values which appeared in the samples treated with IVIg. These results demonstrate that the anti-proliferative activity results from an apoptotic effect of IVIg on the tumor cells. In a second set of experiments, we evaluated the capability of IVIg, when administered orally or subcutaneously, to inhibit the growth of MCA-105 sarcoma lung metastases. A decrease in the mean lung weight was observed in the mice that were treated by s.c. or oral administration, the latter being more effective. A possible role for IVIg in the treatment of MPNST and other soft tissue sarcomas is suggested.

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Copy and paste a formatted citation
Spandidos Publications style
Merimsky O, Meller I, Inbar M, Bar-Yehuda S, Shoenfeld Y and Fishman P: A possible role for IVIg in the treatment of soft tissue sarcoma: A clinical case and an experimental model. Int J Oncol 20: 839-843, 2002.
APA
Merimsky, O., Meller, I., Inbar, M., Bar-Yehuda, S., Shoenfeld, Y., & Fishman, P. (2002). A possible role for IVIg in the treatment of soft tissue sarcoma: A clinical case and an experimental model. International Journal of Oncology, 20, 839-843. https://doi.org/10.3892/ijo.20.4.839
MLA
Merimsky, O., Meller, I., Inbar, M., Bar-Yehuda, S., Shoenfeld, Y., Fishman, P."A possible role for IVIg in the treatment of soft tissue sarcoma: A clinical case and an experimental model". International Journal of Oncology 20.4 (2002): 839-843.
Chicago
Merimsky, O., Meller, I., Inbar, M., Bar-Yehuda, S., Shoenfeld, Y., Fishman, P."A possible role for IVIg in the treatment of soft tissue sarcoma: A clinical case and an experimental model". International Journal of Oncology 20, no. 4 (2002): 839-843. https://doi.org/10.3892/ijo.20.4.839
Copy and paste a formatted citation
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Spandidos Publications style
Merimsky O, Meller I, Inbar M, Bar-Yehuda S, Shoenfeld Y and Fishman P: A possible role for IVIg in the treatment of soft tissue sarcoma: A clinical case and an experimental model. Int J Oncol 20: 839-843, 2002.
APA
Merimsky, O., Meller, I., Inbar, M., Bar-Yehuda, S., Shoenfeld, Y., & Fishman, P. (2002). A possible role for IVIg in the treatment of soft tissue sarcoma: A clinical case and an experimental model. International Journal of Oncology, 20, 839-843. https://doi.org/10.3892/ijo.20.4.839
MLA
Merimsky, O., Meller, I., Inbar, M., Bar-Yehuda, S., Shoenfeld, Y., Fishman, P."A possible role for IVIg in the treatment of soft tissue sarcoma: A clinical case and an experimental model". International Journal of Oncology 20.4 (2002): 839-843.
Chicago
Merimsky, O., Meller, I., Inbar, M., Bar-Yehuda, S., Shoenfeld, Y., Fishman, P."A possible role for IVIg in the treatment of soft tissue sarcoma: A clinical case and an experimental model". International Journal of Oncology 20, no. 4 (2002): 839-843. https://doi.org/10.3892/ijo.20.4.839
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