Occurrence of tumor antigen pRL1a specific CD8 T cells in spleen cells from syngeneic BALB/c, semiallogeneic (BALB/c x C57BL/6)F1 and allogeneic C57BL/6 mice

Hata,Hidenori; Uenaka,Akiko; Takada,Itsuro; Kenjo,Akira; Takahashi,Minoru; Ono,Toshiro; Fujita,Teizo; Nakayama,Eiichi

doi:10.3892/ijo.20.5.1019

May 2002 Volume 20 Issue 5

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May 2002 Volume 20 Issue 5

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Article

Occurrence of tumor antigen pRL1a specific CD8 T cells in spleen cells from syngeneic BALB/c, semiallogeneic (BALB/c x C57BL/6)F1 and allogeneic C57BL/6 mice

Authors:
- Hidenori Hata
- Akiko Uenaka
- Itsuro Takada
- Akira Kenjo
- Minoru Takahashi
- Toshiro Ono
- Teizo Fujita
- Eiichi Nakayama
View Affiliations / Copyright

Affiliations: Department of Immunology, Okayama University Graduate School of Medicine and Dentistry, Okayama 700-8558, Japan
Pages: 1019-1025
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Published online on: May 1, 2002

https://doi.org/10.3892/ijo.20.5.1019
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Abstract

We investigated the generation of CD8 cytotoxic T-lymphocytes (CTL) that recognized a dominant pRL1a peptide bound to H-2Ld molecule on RL male 1 leukemia in spleen cells from RL male 1-bearing syngeneic BALB/c, semiallogeneic CB6F1 and allogeneic B6 mice by repetitive in vitro stimulation with RL male 1 tumor. CD8 T cells in cultures were also analyzed by H-2Ld/pRL1a tetramer staining. We showed that pRL1a-specific CTL were more efficiently generated in spleen cells from RL male 1-bearing high responder CB6F1 mice than in low responder BALB/c mice, and this correlated well with the occurrence of H-2Ld/pRL1a tetramer binding CD8 T cells. Furthermore, we showed that in spleen cells from RL male 1-bearing allogeneic B6 mice, H-2Ld/pRL1a complex specific CD8 T cells were present at a significant frequency. H-2Ld/pRL1a recognizing B6 CTL but not BALB/c or CB6F1 CTL gradually lost CD8 expression on their surface by multiplication of in vitro stimulation.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Occurrence of tumor antigen pRL1a specific CD8 T cells in spleen cells from syngeneic BALB/c, semiallogeneic (BALB/c x C57BL/6)F1 and allogeneic C57BL/6 mice

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