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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 2002 Volume 20 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2002 Volume 20 Issue 5

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Article

Granulocyte macrophage-colony stimulating factor gene transfer to induce a protective anti-tumoral immune response against the 9L rat gliosarcoma model

  • Authors:
    • Florence Lefranc
    • Vincent Cool
    • Thierry Velu
    • Jacques Brotchi
    • Olivier De Witte

  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Erasme Academic Hospital, 1070 Brussels, Belgium. flefranc@hotmail.com
  • Pages: 1077-1085
    |
    Published online on: May 1, 2002
       https://doi.org/10.3892/ijo.20.5.1077
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Abstract

The injection of irradiated tumor cells genetically engineered to express the granolocyte macrophage-colony stimulating factor (GM-CSF) is reported as stimulating antitumoral immunity in several animal models. We used the 9L gliosarcoma rat model to investigate the potency of this strategy in relation to the central nervous system. After in vitro transduction experiments to generate 9L murine cells producing GM-CSF (9LmGM-CSF cells), we found that with the exception of one rat subcutaneously (s.c.) grafted with 108 9LmGM-CSF cells, syngenic rats s.c. injected (dorsal route) with 106-108 viable 9LmGM-CSF cells did not develop s.c. 9L gliosarcomas, while rats s.c. grafted with the same number of naive 9L cells died between 25 and 45 days postgraft. Intracerebral stereotactic injections of 4.104 naive 9L (without s.c. 9LmGM-CSF treatment) killed all the rats within 18-24 days, while s.c. grafting with 108 9LmGM-CSF cells wholly prevented the development of 9L brain gliosarcomas. These results outline the feasibility of the GM-CSF gene transfer approach in glioma (or at least gliosarcoma) gene therapy and could therefore serve as a basis for the development of an adjuvant treatment of glioblastomas using GM-CSF-producing tumor cell vaccines.

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Copy and paste a formatted citation
Spandidos Publications style
Lefranc F, Cool V, Velu T, Brotchi J and De Witte O: Granulocyte macrophage-colony stimulating factor gene transfer to induce a protective anti-tumoral immune response against the 9L rat gliosarcoma model. Int J Oncol 20: 1077-1085, 2002.
APA
Lefranc, F., Cool, V., Velu, T., Brotchi, J., & De Witte, O. (2002). Granulocyte macrophage-colony stimulating factor gene transfer to induce a protective anti-tumoral immune response against the 9L rat gliosarcoma model. International Journal of Oncology, 20, 1077-1085. https://doi.org/10.3892/ijo.20.5.1077
MLA
Lefranc, F., Cool, V., Velu, T., Brotchi, J., De Witte, O."Granulocyte macrophage-colony stimulating factor gene transfer to induce a protective anti-tumoral immune response against the 9L rat gliosarcoma model". International Journal of Oncology 20.5 (2002): 1077-1085.
Chicago
Lefranc, F., Cool, V., Velu, T., Brotchi, J., De Witte, O."Granulocyte macrophage-colony stimulating factor gene transfer to induce a protective anti-tumoral immune response against the 9L rat gliosarcoma model". International Journal of Oncology 20, no. 5 (2002): 1077-1085. https://doi.org/10.3892/ijo.20.5.1077
Copy and paste a formatted citation
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Spandidos Publications style
Lefranc F, Cool V, Velu T, Brotchi J and De Witte O: Granulocyte macrophage-colony stimulating factor gene transfer to induce a protective anti-tumoral immune response against the 9L rat gliosarcoma model. Int J Oncol 20: 1077-1085, 2002.
APA
Lefranc, F., Cool, V., Velu, T., Brotchi, J., & De Witte, O. (2002). Granulocyte macrophage-colony stimulating factor gene transfer to induce a protective anti-tumoral immune response against the 9L rat gliosarcoma model. International Journal of Oncology, 20, 1077-1085. https://doi.org/10.3892/ijo.20.5.1077
MLA
Lefranc, F., Cool, V., Velu, T., Brotchi, J., De Witte, O."Granulocyte macrophage-colony stimulating factor gene transfer to induce a protective anti-tumoral immune response against the 9L rat gliosarcoma model". International Journal of Oncology 20.5 (2002): 1077-1085.
Chicago
Lefranc, F., Cool, V., Velu, T., Brotchi, J., De Witte, O."Granulocyte macrophage-colony stimulating factor gene transfer to induce a protective anti-tumoral immune response against the 9L rat gliosarcoma model". International Journal of Oncology 20, no. 5 (2002): 1077-1085. https://doi.org/10.3892/ijo.20.5.1077
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