NO-releasing NSAIDs and colon cancer chemoprevention: A promising novel approach (Review)

Rigas,Basil; Williams,Jennie L.

doi:10.3892/ijo.20.5.885

May 2002 Volume 20 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Medicine International

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May 2002 Volume 20 Issue 5

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Review

NO-releasing NSAIDs and colon cancer chemoprevention: A promising novel approach (Review)

Authors:
- Basil Rigas
- Jennie L. Williams
View Affiliations / Copyright

Affiliations: American Health Foundation, Valhalla, NY 10595, USA. brigas@ahf.org
Pages: 885-890
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Published online on: May 1, 2002

https://doi.org/10.3892/ijo.20.5.885
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Abstract

The chemoprevention of colon cancer, the second leading cause of cancer-related deaths in the United States, has been pursued actively during the last two decades. Methodological problems and those stemming from the available agents per se have constrained this difficult task; to some extent, these problems persist to date. That NSAIDs decrease the incidence of and mortality from colon cancer has been a major advance in chemoprevention. These compounds are, however, limited by their significant side effects. NO-releasing NSAIDs (NO-NSAIDs) are a novel class of compounds, synthesized to overcome the limitations of NSAIDs. In general, they appear safer and much more effective than their traditional counterparts. We review their structural features, metabolism and pharmacological actions. In vitro and in vivo studies indicate that they are much more effective than traditional NSAIDs in modulating colonocyte kinetics and the formation of premalignant colon lesions. Their mechanism of action is complex and not fully understood, including modulation of NO synthesis, signaling mediated via NF-κB and likely other pathways. Current early findings indicate that NO-NSAIDs may play a highly promising role in the chemoprevention of colon cancer.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

NO-releasing NSAIDs and colon cancer chemoprevention: A promising novel approach (Review)

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Abstract

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