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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 2002 Volume 20 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Characterization of 2 novel and 2 recurring BRCA1 germline mutations in breast and/or ovarian carcinoma patients from the area of Naples

  • Authors:
    • A. Curci
    • I. Capasso
    • A. Romano
    • P. Bruni
    • M. L. Motti
    • S. Pignata
    • G. D'Aiuto
    • A. Casamassimi
    • M. D'Urso
    • A. Fusco
    • G. Viglietto
  • View Affiliations / Copyright

    Affiliations: Istituto Nazionale Tumori, Fondazione Pascale, 80131 Naples, Italy
  • Pages: 963-970
    |
    Published online on: May 1, 2002
       https://doi.org/10.3892/ijo.20.5.963
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Abstract

We have analyzed 18 families with high incidence of breast cancer or breast and ovarian cancer for the presence of BRCA1 mutations. We identified 4 mutations in the BRCA1 gene in 4 unrelated probands who belong to families with at least 1 case of breast and 1 case of ovarian cancer. Two of the mutations reported in this study are novel (GAA1172↷TAA in family Naples 14, GAA1765↷TAA in family Naples 20) whereas the others are already present in the Breast Cancer Information Core Electronic Database (http://nchgr.nih.gov/ Intramural research/Lab transfer/Bic/) (5382insC in family Naples 18 and 2080delA in family Naples 19). Conversely, no mutation in the BRCA1 gene was detected in 14 families characterized by 2 or more cases of breast cancer only, even if bilateral and with early-onset. These results indicate that germline mutations in the BRCA1 gene highly predispose for a cancer syndrome that involves the presence of both breast and ovarian cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Curci A, Capasso I, Romano A, Bruni P, Motti ML, Pignata S, D'Aiuto G, Casamassimi A, D'Urso M, Fusco A, Fusco A, et al: Characterization of 2 novel and 2 recurring BRCA1 germline mutations in breast and/or ovarian carcinoma patients from the area of Naples. Int J Oncol 20: 963-970, 2002.
APA
Curci, A., Capasso, I., Romano, A., Bruni, P., Motti, M.L., Pignata, S. ... Viglietto, G. (2002). Characterization of 2 novel and 2 recurring BRCA1 germline mutations in breast and/or ovarian carcinoma patients from the area of Naples. International Journal of Oncology, 20, 963-970. https://doi.org/10.3892/ijo.20.5.963
MLA
Curci, A., Capasso, I., Romano, A., Bruni, P., Motti, M. L., Pignata, S., D'Aiuto, G., Casamassimi, A., D'Urso, M., Fusco, A., Viglietto, G."Characterization of 2 novel and 2 recurring BRCA1 germline mutations in breast and/or ovarian carcinoma patients from the area of Naples". International Journal of Oncology 20.5 (2002): 963-970.
Chicago
Curci, A., Capasso, I., Romano, A., Bruni, P., Motti, M. L., Pignata, S., D'Aiuto, G., Casamassimi, A., D'Urso, M., Fusco, A., Viglietto, G."Characterization of 2 novel and 2 recurring BRCA1 germline mutations in breast and/or ovarian carcinoma patients from the area of Naples". International Journal of Oncology 20, no. 5 (2002): 963-970. https://doi.org/10.3892/ijo.20.5.963
Copy and paste a formatted citation
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Spandidos Publications style
Curci A, Capasso I, Romano A, Bruni P, Motti ML, Pignata S, D'Aiuto G, Casamassimi A, D'Urso M, Fusco A, Fusco A, et al: Characterization of 2 novel and 2 recurring BRCA1 germline mutations in breast and/or ovarian carcinoma patients from the area of Naples. Int J Oncol 20: 963-970, 2002.
APA
Curci, A., Capasso, I., Romano, A., Bruni, P., Motti, M.L., Pignata, S. ... Viglietto, G. (2002). Characterization of 2 novel and 2 recurring BRCA1 germline mutations in breast and/or ovarian carcinoma patients from the area of Naples. International Journal of Oncology, 20, 963-970. https://doi.org/10.3892/ijo.20.5.963
MLA
Curci, A., Capasso, I., Romano, A., Bruni, P., Motti, M. L., Pignata, S., D'Aiuto, G., Casamassimi, A., D'Urso, M., Fusco, A., Viglietto, G."Characterization of 2 novel and 2 recurring BRCA1 germline mutations in breast and/or ovarian carcinoma patients from the area of Naples". International Journal of Oncology 20.5 (2002): 963-970.
Chicago
Curci, A., Capasso, I., Romano, A., Bruni, P., Motti, M. L., Pignata, S., D'Aiuto, G., Casamassimi, A., D'Urso, M., Fusco, A., Viglietto, G."Characterization of 2 novel and 2 recurring BRCA1 germline mutations in breast and/or ovarian carcinoma patients from the area of Naples". International Journal of Oncology 20, no. 5 (2002): 963-970. https://doi.org/10.3892/ijo.20.5.963
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