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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 2002 Volume 20 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2002 Volume 20 Issue 5

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Article

A rapid screening assay for antioxidant potential of natural and synthetic agents in vitro

  • Authors:
    • Praveen Srinivasan
    • Manicka V. Vadhanam
    • Jamal M. Arif
    • Ramesh C. Gupta

  • View Affiliations / Copyright

    Affiliations: Stanford University, Stanford, CA 94309, USA
  • Pages: 983-986
    |
    Published online on: May 1, 2002
       https://doi.org/10.3892/ijo.20.5.983
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Abstract

There are literally thousands of known agents with potential chemopreventive and antioxidant activity; however, the expanding list of natural and synthetic compounds makes it difficult to test every agent in the widely accepted 2-year animal bioassay and human clinical trials. Therefore, short-term screening assays are needed to sort out the most efficacious compounds for long-term animal studies. In the present study, the identification of chemopreventive agents with efficacious antioxidant potential was explored with a Cu2+-mediated Fenton-type reaction, coupled with oxidative DNA lesion detection by 32P-postlabeling. Several agents inhibited the formation of 8-oxo-2'-deoxyguanosine (8-oxodG), a benchmark oxidative DNA lesion, but ellagic acid, a polyphenol found in berries, offered maximal (>80%) inhibition of 8-oxodG formation. However, a well-known tea polyphenol, epigallocatechin gallate, along with silymarin and D,L-sulforaphane, exhibited a pro-oxidant effect, with 50-70% increase in 8-oxodG induction. In general, our results agree with the reported antioxidant - pro-oxidant activities of the compounds, rendering this in vitro screening assay to be useful in determining the antioxidant potential of compounds rapidly and cost-effectively.

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Copy and paste a formatted citation
Spandidos Publications style
Srinivasan P, Vadhanam MV, Arif JM and Gupta RC: A rapid screening assay for antioxidant potential of natural and synthetic agents in vitro. Int J Oncol 20: 983-986, 2002.
APA
Srinivasan, P., Vadhanam, M.V., Arif, J.M., & Gupta, R.C. (2002). A rapid screening assay for antioxidant potential of natural and synthetic agents in vitro. International Journal of Oncology, 20, 983-986. https://doi.org/10.3892/ijo.20.5.983
MLA
Srinivasan, P., Vadhanam, M. V., Arif, J. M., Gupta, R. C."A rapid screening assay for antioxidant potential of natural and synthetic agents in vitro". International Journal of Oncology 20.5 (2002): 983-986.
Chicago
Srinivasan, P., Vadhanam, M. V., Arif, J. M., Gupta, R. C."A rapid screening assay for antioxidant potential of natural and synthetic agents in vitro". International Journal of Oncology 20, no. 5 (2002): 983-986. https://doi.org/10.3892/ijo.20.5.983
Copy and paste a formatted citation
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Spandidos Publications style
Srinivasan P, Vadhanam MV, Arif JM and Gupta RC: A rapid screening assay for antioxidant potential of natural and synthetic agents in vitro. Int J Oncol 20: 983-986, 2002.
APA
Srinivasan, P., Vadhanam, M.V., Arif, J.M., & Gupta, R.C. (2002). A rapid screening assay for antioxidant potential of natural and synthetic agents in vitro. International Journal of Oncology, 20, 983-986. https://doi.org/10.3892/ijo.20.5.983
MLA
Srinivasan, P., Vadhanam, M. V., Arif, J. M., Gupta, R. C."A rapid screening assay for antioxidant potential of natural and synthetic agents in vitro". International Journal of Oncology 20.5 (2002): 983-986.
Chicago
Srinivasan, P., Vadhanam, M. V., Arif, J. M., Gupta, R. C."A rapid screening assay for antioxidant potential of natural and synthetic agents in vitro". International Journal of Oncology 20, no. 5 (2002): 983-986. https://doi.org/10.3892/ijo.20.5.983
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