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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 2002 Volume 20 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2002 Volume 20 Issue 5

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Expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines: Up-regulation of WNT8B mRNA by β-estradiol in MCF-7 cells, and down-regulation of WNT8A and WNT8B mRNAs by retinoic acid in NT2 cells

  • Authors:
    • Tetsuroh Saitoh
    • Tetsuya Mine
    • Masaru Katoh

  • View Affiliations / Copyright

    Affiliations: Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tokyo 104-0045, Japan
  • Pages: 999-1003
    |
    Published online on: May 1, 2002
       https://doi.org/10.3892/ijo.20.5.999
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Abstract

Xenopus wnt-8 (Xwnt-8) is one of the most potent Wnts to activate the WNT - β-catenin - TCF signaling pathway. We have previously cloned and characterized WNT8A and WNT8B, two human homologues of Xwnt-8. Here, we investigated expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines by using cDNA-PCR. WNT8A mRNA was undetectable in 7 pancreatic cancer cell lines, but WNT8B mRNA was detected in pancreatic cancer cell lines PSN-1, BxPC-3, MIA PaCa-2. Both WNT8A and WNT8B mRNAs were undetectable in 7 brain tumor cell lines. Although WNT8A mRNA was undetectable in 3 breast cancer cell lines, WNT8B mRNA was detected in the breast cancer cell line MCF-7. WNT8B mRNA, but not WNT8A mRNA, was significantly up-regulated by β-estradiol in MCF-7 cells. WNT8A mRNA was detected in embryonal tumor cell lines NEC-14, NCC-IT, and NT2, while WNT8B mRNA was detected in embryonal tumor cell lines NEC-8, NEC-14, and NT2. Because NT2 cells differentiate into neuronal cells after all-trans retinoic-acid treatment, effects of all-trans retinoic acid on mRNA expression of WNT8A and WNT8B were next investigated. WNT8A and WNT8B mRNAs were down-regulated together in NT2 cells after all-trans retinoic-acid treatment. WNT8A and WNT8B might play key roles in embryonal tumors and embryonic stem cells through synergistic activation of the β-catenin - TCF signaling pathway.

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Copy and paste a formatted citation
Spandidos Publications style
Saitoh T, Mine T and Katoh M: Expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines: Up-regulation of WNT8B mRNA by β-estradiol in MCF-7 cells, and down-regulation of WNT8A and WNT8B mRNAs by retinoic acid in NT2 cells. Int J Oncol 20: 999-1003, 2002.
APA
Saitoh, T., Mine, T., & Katoh, M. (2002). Expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines: Up-regulation of WNT8B mRNA by β-estradiol in MCF-7 cells, and down-regulation of WNT8A and WNT8B mRNAs by retinoic acid in NT2 cells. International Journal of Oncology, 20, 999-1003. https://doi.org/10.3892/ijo.20.5.999
MLA
Saitoh, T., Mine, T., Katoh, M."Expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines: Up-regulation of WNT8B mRNA by β-estradiol in MCF-7 cells, and down-regulation of WNT8A and WNT8B mRNAs by retinoic acid in NT2 cells". International Journal of Oncology 20.5 (2002): 999-1003.
Chicago
Saitoh, T., Mine, T., Katoh, M."Expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines: Up-regulation of WNT8B mRNA by β-estradiol in MCF-7 cells, and down-regulation of WNT8A and WNT8B mRNAs by retinoic acid in NT2 cells". International Journal of Oncology 20, no. 5 (2002): 999-1003. https://doi.org/10.3892/ijo.20.5.999
Copy and paste a formatted citation
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Spandidos Publications style
Saitoh T, Mine T and Katoh M: Expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines: Up-regulation of WNT8B mRNA by β-estradiol in MCF-7 cells, and down-regulation of WNT8A and WNT8B mRNAs by retinoic acid in NT2 cells. Int J Oncol 20: 999-1003, 2002.
APA
Saitoh, T., Mine, T., & Katoh, M. (2002). Expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines: Up-regulation of WNT8B mRNA by β-estradiol in MCF-7 cells, and down-regulation of WNT8A and WNT8B mRNAs by retinoic acid in NT2 cells. International Journal of Oncology, 20, 999-1003. https://doi.org/10.3892/ijo.20.5.999
MLA
Saitoh, T., Mine, T., Katoh, M."Expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines: Up-regulation of WNT8B mRNA by β-estradiol in MCF-7 cells, and down-regulation of WNT8A and WNT8B mRNAs by retinoic acid in NT2 cells". International Journal of Oncology 20.5 (2002): 999-1003.
Chicago
Saitoh, T., Mine, T., Katoh, M."Expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines: Up-regulation of WNT8B mRNA by β-estradiol in MCF-7 cells, and down-regulation of WNT8A and WNT8B mRNAs by retinoic acid in NT2 cells". International Journal of Oncology 20, no. 5 (2002): 999-1003. https://doi.org/10.3892/ijo.20.5.999
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