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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2011 Volume 38 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2011 Volume 38 Issue 2

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Article

Antitumor effect of endostatin overexpressed in C6 glioma cells is associated with the down-regulation of VEGF

  • Authors:
    • Lijuan Yang
    • Zhixiong Lin
    • Jianhua Lin
    • Shenmei Weng
    • Qian Huang
    • Pengfei Zhang
    • Jin Fu

  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, P.R. China, Department of Neurosurgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, P.R. China, Laboratory of Tumorous Invasion Microecosystem, Fujian Medical University, P.R. China
  • Pages: 465-471
    |
    Published online on: December 14, 2010
       https://doi.org/10.3892/ijo.2010.871
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Abstract

Endostatin is an anti-angiogenic agent that blocks endothelial cell proliferation, tumor growth, and metastasis. Several lines of direct evidence show that gliomas express high levels of endostatin. However, the anti-angiogenic activity and cellular mechanisms of endostatin from tumor cells have not been completely elucidated. In this study, we established C6 glioblastoma (GBM) xenografts in nude mice by subcutaneously injecting glioma cell lines, C6-null cells, and stable transfected-C6 cells overexpressing mock vector (C6-mock) and endostatin (C6-endo). We found that overexpression of endostatin in C6-endo cells significantly suppressed the expression of VEGF in tumor cells in vivo as well as in vitro. Furthermore, the tumor growth derived from C6-endo cells was inhibited. Our data demonstrate that endostatin could play a direct role in inhibiting tumor cells, and suggest that enhancing endostatin expression in gliomas could be an effective treatment strategy.

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Copy and paste a formatted citation
Spandidos Publications style
Yang L, Lin Z, Lin J, Weng S, Huang Q, Zhang P and Fu J: Antitumor effect of endostatin overexpressed in C6 glioma cells is associated with the down-regulation of VEGF. Int J Oncol 38: 465-471, 2011.
APA
Yang, L., Lin, Z., Lin, J., Weng, S., Huang, Q., Zhang, P., & Fu, J. (2011). Antitumor effect of endostatin overexpressed in C6 glioma cells is associated with the down-regulation of VEGF. International Journal of Oncology, 38, 465-471. https://doi.org/10.3892/ijo.2010.871
MLA
Yang, L., Lin, Z., Lin, J., Weng, S., Huang, Q., Zhang, P., Fu, J."Antitumor effect of endostatin overexpressed in C6 glioma cells is associated with the down-regulation of VEGF". International Journal of Oncology 38.2 (2011): 465-471.
Chicago
Yang, L., Lin, Z., Lin, J., Weng, S., Huang, Q., Zhang, P., Fu, J."Antitumor effect of endostatin overexpressed in C6 glioma cells is associated with the down-regulation of VEGF". International Journal of Oncology 38, no. 2 (2011): 465-471. https://doi.org/10.3892/ijo.2010.871
Copy and paste a formatted citation
x
Spandidos Publications style
Yang L, Lin Z, Lin J, Weng S, Huang Q, Zhang P and Fu J: Antitumor effect of endostatin overexpressed in C6 glioma cells is associated with the down-regulation of VEGF. Int J Oncol 38: 465-471, 2011.
APA
Yang, L., Lin, Z., Lin, J., Weng, S., Huang, Q., Zhang, P., & Fu, J. (2011). Antitumor effect of endostatin overexpressed in C6 glioma cells is associated with the down-regulation of VEGF. International Journal of Oncology, 38, 465-471. https://doi.org/10.3892/ijo.2010.871
MLA
Yang, L., Lin, Z., Lin, J., Weng, S., Huang, Q., Zhang, P., Fu, J."Antitumor effect of endostatin overexpressed in C6 glioma cells is associated with the down-regulation of VEGF". International Journal of Oncology 38.2 (2011): 465-471.
Chicago
Yang, L., Lin, Z., Lin, J., Weng, S., Huang, Q., Zhang, P., Fu, J."Antitumor effect of endostatin overexpressed in C6 glioma cells is associated with the down-regulation of VEGF". International Journal of Oncology 38, no. 2 (2011): 465-471. https://doi.org/10.3892/ijo.2010.871
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