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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2011 Volume 39 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2011 Volume 39 Issue 1

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Article

Overexpression of α1,6-fucosyltransferase in hepatoma enhances expression of Golgi phosphoprotein 2 in a fucosylation-independent manner

  • Authors:
    • Sayuri Kawamoto
    • Kenta Moriwaki
    • Tsutomu Nakagawa
    • Mika Terao
    • Shinichiro Shinzaki
    • Naoko Yamane-Ohnuki
    • Mitsuo Satoh
    • Anand S. Mehta
    • Timothy M. Block
    • Eiji Miyoshi

  • View Affiliations / Copyright

    Affiliations: Department of Molecular Biochemistry and Clinical Investigation, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan, Department of Molecular Biochemistry and Clinical Investigation, Osaka University Graduate School of Medicine, 1-7 Yamada-oka, Suita, Osaka 565-0871, Japan
  • Pages: 203-208
    |
    Published online on: April 14, 2011
       https://doi.org/10.3892/ijo.2011.1005
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Abstract

Golgi phosphoprotein 2 (GP73) is a type II Golgi protein, which was found on examination of the fucosylated proteome as a potential tumor marker for hepatocellular carcinoma (HCC). The serum levels of both total and fucosylated GP73 were increased in the sera of patients with HCC. Fucosylation is one of the most important oligosaccharide modifications involved in cancer and is catalyzed by α1,6-fucosyltransferase (Fut8). In the present study, we investigated the effect of Fut8 overexpression on GP73 production in the human hepatoma cell line Hep3B. The Fut8 expression vector was transfected into Hep3B cells and the expression of GP73 was investigated by Western blotting and real-time PCR. Overexpression of Fut8 dramatically enhanced the expression of GP73 at the transcriptional level. Surprisingly, this effect was not dependent on cellular fucosylation. Overexpression of a mutant Fut8, which was unable to be localized to the Golgi, did not induce GP73 production, suggesting that the localization of Fut8 in the Golgi apparatus was important for the increase in GP73 expression. This is the first demonstration of GP73 regulation through overexpression of a glycosyltransferase, which may lead to Golgi stress.

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Copy and paste a formatted citation
Spandidos Publications style
Kawamoto S, Moriwaki K, Nakagawa T, Terao M, Shinzaki S, Yamane-Ohnuki N, Satoh M, Mehta AS, Block TM, Miyoshi E, Miyoshi E, et al: Overexpression of α1,6-fucosyltransferase in hepatoma enhances expression of Golgi phosphoprotein 2 in a fucosylation-independent manner. Int J Oncol 39: 203-208, 2011.
APA
Kawamoto, S., Moriwaki, K., Nakagawa, T., Terao, M., Shinzaki, S., Yamane-Ohnuki, N. ... Miyoshi, E. (2011). Overexpression of α1,6-fucosyltransferase in hepatoma enhances expression of Golgi phosphoprotein 2 in a fucosylation-independent manner. International Journal of Oncology, 39, 203-208. https://doi.org/10.3892/ijo.2011.1005
MLA
Kawamoto, S., Moriwaki, K., Nakagawa, T., Terao, M., Shinzaki, S., Yamane-Ohnuki, N., Satoh, M., Mehta, A. S., Block, T. M., Miyoshi, E."Overexpression of α1,6-fucosyltransferase in hepatoma enhances expression of Golgi phosphoprotein 2 in a fucosylation-independent manner". International Journal of Oncology 39.1 (2011): 203-208.
Chicago
Kawamoto, S., Moriwaki, K., Nakagawa, T., Terao, M., Shinzaki, S., Yamane-Ohnuki, N., Satoh, M., Mehta, A. S., Block, T. M., Miyoshi, E."Overexpression of α1,6-fucosyltransferase in hepatoma enhances expression of Golgi phosphoprotein 2 in a fucosylation-independent manner". International Journal of Oncology 39, no. 1 (2011): 203-208. https://doi.org/10.3892/ijo.2011.1005
Copy and paste a formatted citation
x
Spandidos Publications style
Kawamoto S, Moriwaki K, Nakagawa T, Terao M, Shinzaki S, Yamane-Ohnuki N, Satoh M, Mehta AS, Block TM, Miyoshi E, Miyoshi E, et al: Overexpression of α1,6-fucosyltransferase in hepatoma enhances expression of Golgi phosphoprotein 2 in a fucosylation-independent manner. Int J Oncol 39: 203-208, 2011.
APA
Kawamoto, S., Moriwaki, K., Nakagawa, T., Terao, M., Shinzaki, S., Yamane-Ohnuki, N. ... Miyoshi, E. (2011). Overexpression of α1,6-fucosyltransferase in hepatoma enhances expression of Golgi phosphoprotein 2 in a fucosylation-independent manner. International Journal of Oncology, 39, 203-208. https://doi.org/10.3892/ijo.2011.1005
MLA
Kawamoto, S., Moriwaki, K., Nakagawa, T., Terao, M., Shinzaki, S., Yamane-Ohnuki, N., Satoh, M., Mehta, A. S., Block, T. M., Miyoshi, E."Overexpression of α1,6-fucosyltransferase in hepatoma enhances expression of Golgi phosphoprotein 2 in a fucosylation-independent manner". International Journal of Oncology 39.1 (2011): 203-208.
Chicago
Kawamoto, S., Moriwaki, K., Nakagawa, T., Terao, M., Shinzaki, S., Yamane-Ohnuki, N., Satoh, M., Mehta, A. S., Block, T. M., Miyoshi, E."Overexpression of α1,6-fucosyltransferase in hepatoma enhances expression of Golgi phosphoprotein 2 in a fucosylation-independent manner". International Journal of Oncology 39, no. 1 (2011): 203-208. https://doi.org/10.3892/ijo.2011.1005
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