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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2011 Volume 39 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Endosialin is expressed in high grade and advanced sarcomas: Evidence from clinical specimens and preclinical modeling

  • Authors:
    • Cecile Rouleau
    • Robert Smale
    • Yao-Shi Fu
    • Guodong Hui
    • Fei Wang
    • Elizabeth Hutto
    • Robert Fogle
    • Craig M. Jones
    • Roy Krumbholz
    • Stephanie Roth
    • Maritza Curiel
    • Yi Ren
    • Rebecca G. Bagley
    • Gina Wallar
    • Glenn Miller
    • Steven Schmid
    • Bruce Horten
    • Beverly A. Teicher
  • View Affiliations / Copyright

    Affiliations: Genzyme Corporation, Framingham, MA, USA, Developmental Therapeutics Program, National Cancer Institute, 6130 Executive Boulevard, Rockville, MD 20852, USA
  • Pages: 73-89
    |
    Published online on: April 29, 2011
       https://doi.org/10.3892/ijo.2011.1020
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Abstract

We previously surveyed the expression of endosialin/ CD248/TEM-1 by immunohistochemistry in human clinical specimens of sarcomas and documented expression in tumor cells, stromal cells and vasculature. In the present study, we completed a retrospective analysis of the diagnostic reports available for these same samples in order to identify high-grade and metastatic disease. Our results show that endosialin can be detected in advanced disease. We screened human sarcoma cell lines in vitro for endosialin expression and developed preclinical human xenograft models of disseminated sarcoma. We found that 22 out of 42 human sarcoma cell lines were positive for endosialin with a positive correlation between mRNA and protein levels. When implanted in vivo, endosialin was expressed at all sites of dissemination. These data provide clinical and preclinical evidence that endosialin can be detected in advanced sarcoma. These results demonstrate for the first time that endosialin is a suitable therapeutic target for poor prognosis and advanced disease.

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Copy and paste a formatted citation
Spandidos Publications style
Rouleau C, Smale R, Fu Y, Hui G, Wang F, Hutto E, Fogle R, Jones CM, Krumbholz R, Roth S, Roth S, et al: Endosialin is expressed in high grade and advanced sarcomas: Evidence from clinical specimens and preclinical modeling. Int J Oncol 39: 73-89, 2011.
APA
Rouleau, C., Smale, R., Fu, Y., Hui, G., Wang, F., Hutto, E. ... Teicher, B.A. (2011). Endosialin is expressed in high grade and advanced sarcomas: Evidence from clinical specimens and preclinical modeling. International Journal of Oncology, 39, 73-89. https://doi.org/10.3892/ijo.2011.1020
MLA
Rouleau, C., Smale, R., Fu, Y., Hui, G., Wang, F., Hutto, E., Fogle, R., Jones, C. M., Krumbholz, R., Roth, S., Curiel, M., Ren, Y., Bagley, R. G., Wallar, G., Miller, G., Schmid, S., Horten, B., Teicher, B. A."Endosialin is expressed in high grade and advanced sarcomas: Evidence from clinical specimens and preclinical modeling". International Journal of Oncology 39.1 (2011): 73-89.
Chicago
Rouleau, C., Smale, R., Fu, Y., Hui, G., Wang, F., Hutto, E., Fogle, R., Jones, C. M., Krumbholz, R., Roth, S., Curiel, M., Ren, Y., Bagley, R. G., Wallar, G., Miller, G., Schmid, S., Horten, B., Teicher, B. A."Endosialin is expressed in high grade and advanced sarcomas: Evidence from clinical specimens and preclinical modeling". International Journal of Oncology 39, no. 1 (2011): 73-89. https://doi.org/10.3892/ijo.2011.1020
Copy and paste a formatted citation
x
Spandidos Publications style
Rouleau C, Smale R, Fu Y, Hui G, Wang F, Hutto E, Fogle R, Jones CM, Krumbholz R, Roth S, Roth S, et al: Endosialin is expressed in high grade and advanced sarcomas: Evidence from clinical specimens and preclinical modeling. Int J Oncol 39: 73-89, 2011.
APA
Rouleau, C., Smale, R., Fu, Y., Hui, G., Wang, F., Hutto, E. ... Teicher, B.A. (2011). Endosialin is expressed in high grade and advanced sarcomas: Evidence from clinical specimens and preclinical modeling. International Journal of Oncology, 39, 73-89. https://doi.org/10.3892/ijo.2011.1020
MLA
Rouleau, C., Smale, R., Fu, Y., Hui, G., Wang, F., Hutto, E., Fogle, R., Jones, C. M., Krumbholz, R., Roth, S., Curiel, M., Ren, Y., Bagley, R. G., Wallar, G., Miller, G., Schmid, S., Horten, B., Teicher, B. A."Endosialin is expressed in high grade and advanced sarcomas: Evidence from clinical specimens and preclinical modeling". International Journal of Oncology 39.1 (2011): 73-89.
Chicago
Rouleau, C., Smale, R., Fu, Y., Hui, G., Wang, F., Hutto, E., Fogle, R., Jones, C. M., Krumbholz, R., Roth, S., Curiel, M., Ren, Y., Bagley, R. G., Wallar, G., Miller, G., Schmid, S., Horten, B., Teicher, B. A."Endosialin is expressed in high grade and advanced sarcomas: Evidence from clinical specimens and preclinical modeling". International Journal of Oncology 39, no. 1 (2011): 73-89. https://doi.org/10.3892/ijo.2011.1020
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