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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2011 Volume 39 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Intracellular estrogen receptor-binding fragment-associated antigen 9 exerts in vivo tumor-promoting effects via its coiled-coil region

  • Authors:
    • Yoshihiro Maeyama
    • Makoto Otsu
    • Shuji Kubo
    • Tomoki Yamano
    • Yasuaki Iimura
    • Masafumi Onodera
    • Satoshi Kondo
    • Yukio Sakiyama
    • Tadashi Ariga

  • View Affiliations / Copyright

    Affiliations: Group of Human Gene Therapy, Hokkaido University Graduate School of Medicine, N15W7 Sapporo, Hokkaido 060-8638, Japan, Department of Genetics, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan, Department of Pediatrics, Hokkaido University Graduate School of Medicine, N15W7 Sapporo, Hokkaido 060-8638, Japan
  • Pages: 41-49
    |
    Published online on: May 3, 2011
       https://doi.org/10.3892/ijo.2011.1026
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Abstract

Estrogen receptor-binding fragment-associated antigen 9 (EBAG9) is a tumor-promoting factor of largely unknown function. To assess a causative role of EBAG9 in advanced malignancies, we generated the EG7-OVA and MethA murine tumor cell lines that stably express full-length or truncated EBAG9 protein, using retroviral-mediated gene transduction. Upon subcutaneous inoculation into immunocompetent mice, both cell lines showed marked acceleration of in vivo tumor growth when full-length EBAG9 was overexpressed. Interestingly, deletion of the coiled-coil region, thereby producing truncated EBAG9 protein, abolished the tumor-acceleration effect, establishing the importance of this domain in EBAG9-mediated tumor promotion. However, there was no alteration in in vitro cell proliferation or expression levels of MHC class I and co-stimulatory molecules believed to play a role in immune evasion of tumor cells in these tumor cell lines expressing full-length or truncated EBAG9 protein. Furthermore, both full-length and truncated EBAG9 proteins showed a predominantly cytoplasmic localization in the tumor cells. Collectively, these results suggest that EBAG9 overexpression can be causative in enhancing the malignant properties of tumor cells, and that tumor promotion likely requires EBAG9 intracellular association with as yet unidentified binding partners via the coiled-coil region.

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Copy and paste a formatted citation
Spandidos Publications style
Maeyama Y, Otsu M, Kubo S, Yamano T, Iimura Y, Onodera M, Kondo S, Sakiyama Y and Ariga T: Intracellular estrogen receptor-binding fragment-associated antigen 9 exerts in vivo tumor-promoting effects via its coiled-coil region. Int J Oncol 39: 41-49, 2011.
APA
Maeyama, Y., Otsu, M., Kubo, S., Yamano, T., Iimura, Y., Onodera, M. ... Ariga, T. (2011). Intracellular estrogen receptor-binding fragment-associated antigen 9 exerts in vivo tumor-promoting effects via its coiled-coil region. International Journal of Oncology, 39, 41-49. https://doi.org/10.3892/ijo.2011.1026
MLA
Maeyama, Y., Otsu, M., Kubo, S., Yamano, T., Iimura, Y., Onodera, M., Kondo, S., Sakiyama, Y., Ariga, T."Intracellular estrogen receptor-binding fragment-associated antigen 9 exerts in vivo tumor-promoting effects via its coiled-coil region". International Journal of Oncology 39.1 (2011): 41-49.
Chicago
Maeyama, Y., Otsu, M., Kubo, S., Yamano, T., Iimura, Y., Onodera, M., Kondo, S., Sakiyama, Y., Ariga, T."Intracellular estrogen receptor-binding fragment-associated antigen 9 exerts in vivo tumor-promoting effects via its coiled-coil region". International Journal of Oncology 39, no. 1 (2011): 41-49. https://doi.org/10.3892/ijo.2011.1026
Copy and paste a formatted citation
x
Spandidos Publications style
Maeyama Y, Otsu M, Kubo S, Yamano T, Iimura Y, Onodera M, Kondo S, Sakiyama Y and Ariga T: Intracellular estrogen receptor-binding fragment-associated antigen 9 exerts in vivo tumor-promoting effects via its coiled-coil region. Int J Oncol 39: 41-49, 2011.
APA
Maeyama, Y., Otsu, M., Kubo, S., Yamano, T., Iimura, Y., Onodera, M. ... Ariga, T. (2011). Intracellular estrogen receptor-binding fragment-associated antigen 9 exerts in vivo tumor-promoting effects via its coiled-coil region. International Journal of Oncology, 39, 41-49. https://doi.org/10.3892/ijo.2011.1026
MLA
Maeyama, Y., Otsu, M., Kubo, S., Yamano, T., Iimura, Y., Onodera, M., Kondo, S., Sakiyama, Y., Ariga, T."Intracellular estrogen receptor-binding fragment-associated antigen 9 exerts in vivo tumor-promoting effects via its coiled-coil region". International Journal of Oncology 39.1 (2011): 41-49.
Chicago
Maeyama, Y., Otsu, M., Kubo, S., Yamano, T., Iimura, Y., Onodera, M., Kondo, S., Sakiyama, Y., Ariga, T."Intracellular estrogen receptor-binding fragment-associated antigen 9 exerts in vivo tumor-promoting effects via its coiled-coil region". International Journal of Oncology 39, no. 1 (2011): 41-49. https://doi.org/10.3892/ijo.2011.1026
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