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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2011 Volume 39 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2011 Volume 39 Issue 1

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Article

High incidence of high-risk HPV in benign and malignant lesions of the larynx

  • Authors:
    • Anaëlle Duray
    • Géraldine Descamps
    • Mohammad Arafa
    • Christine Decaestecker
    • Myriam Remmelink
    • Nicolas Sirtaine
    • Perle Ernoux-Neufcoeur
    • Eugène Mutijima
    • Joan Somja
    • Christophe E. Depuydt
    • Philippe Delvenne
    • Sven Saussez

  • View Affiliations / Copyright

    Affiliations: Laboratory of Anatomy, Faculty of Medicine and Pharmacy, University of Mons, Mons, Belgium, Laboratory of Anatomy, Faculty of Medicine and Pharmacy, University of Mons, Pentagone 2A-Avenue du Champ de Mars 6, B-7000 Mons, Belgium
  • Pages: 51-59
    |
    Published online on: May 4, 2011
       https://doi.org/10.3892/ijo.2011.1031
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Abstract

The aim of this study was to determine the prevalence of human papillomavirus (HPV) in patients with laryngeal benign lesions (LBLs) and laryngeal squamous cell carcinomas (LSCCs) using a sensitive E6/E7 type-specific PCR. Paraffin-embedded samples from LBL (n=39) and LSCC patients (n=67) were evaluated for the presence of HPV DNA by GP5+/GP6+ consensus PCR and E6/E7 type-specific PCR for HPV types 6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66 and 68. In LSCCs, immunohistochemical staining of p16, p53 and EGFR was also assessed. The E6/E7 type-specific PCR showed that 44 out of 59 LSCC patients (i.e., 75%) had high-risk (hr) HPV types and that 27 out of 35 LBL patients (i.e., 77%) had hrHPV types. HPV-16 viral load was significantly higher in LSCC than in LBL patients (p<10-6). The presence of hrHPV DNA did not correlate with the proportion of disease-free patients. Comparable levels of p16, p53 and EGFR expression were observed in the hrHPV+ tumor group (100% p16+, 56% p53+ and 97% EGFR+) and in the HPV- or low-risk (lr) HPV+ tumor group (92% p16+, 66% p53+ and 100% EGFR+). A very high prevalence of oncogenic HPV-16 was found in a series of benign and malignant laryngeal lesions. LSCC appears to be characterized by an active hrHPV infection. In LSCCs, the hrHPV+ subgroup had a similar prognosis (in terms of risk of recurrence) as the HPV- subgroup.

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Copy and paste a formatted citation
Spandidos Publications style
Duray A, Descamps G, Arafa M, Decaestecker C, Remmelink M, Sirtaine N, Ernoux-Neufcoeur P, Mutijima E, Somja J, Depuydt CE, Depuydt CE, et al: High incidence of high-risk HPV in benign and malignant lesions of the larynx. Int J Oncol 39: 51-59, 2011.
APA
Duray, A., Descamps, G., Arafa, M., Decaestecker, C., Remmelink, M., Sirtaine, N. ... Saussez, S. (2011). High incidence of high-risk HPV in benign and malignant lesions of the larynx. International Journal of Oncology, 39, 51-59. https://doi.org/10.3892/ijo.2011.1031
MLA
Duray, A., Descamps, G., Arafa, M., Decaestecker, C., Remmelink, M., Sirtaine, N., Ernoux-Neufcoeur, P., Mutijima, E., Somja, J., Depuydt, C. E., Delvenne, P., Saussez, S."High incidence of high-risk HPV in benign and malignant lesions of the larynx". International Journal of Oncology 39.1 (2011): 51-59.
Chicago
Duray, A., Descamps, G., Arafa, M., Decaestecker, C., Remmelink, M., Sirtaine, N., Ernoux-Neufcoeur, P., Mutijima, E., Somja, J., Depuydt, C. E., Delvenne, P., Saussez, S."High incidence of high-risk HPV in benign and malignant lesions of the larynx". International Journal of Oncology 39, no. 1 (2011): 51-59. https://doi.org/10.3892/ijo.2011.1031
Copy and paste a formatted citation
x
Spandidos Publications style
Duray A, Descamps G, Arafa M, Decaestecker C, Remmelink M, Sirtaine N, Ernoux-Neufcoeur P, Mutijima E, Somja J, Depuydt CE, Depuydt CE, et al: High incidence of high-risk HPV in benign and malignant lesions of the larynx. Int J Oncol 39: 51-59, 2011.
APA
Duray, A., Descamps, G., Arafa, M., Decaestecker, C., Remmelink, M., Sirtaine, N. ... Saussez, S. (2011). High incidence of high-risk HPV in benign and malignant lesions of the larynx. International Journal of Oncology, 39, 51-59. https://doi.org/10.3892/ijo.2011.1031
MLA
Duray, A., Descamps, G., Arafa, M., Decaestecker, C., Remmelink, M., Sirtaine, N., Ernoux-Neufcoeur, P., Mutijima, E., Somja, J., Depuydt, C. E., Delvenne, P., Saussez, S."High incidence of high-risk HPV in benign and malignant lesions of the larynx". International Journal of Oncology 39.1 (2011): 51-59.
Chicago
Duray, A., Descamps, G., Arafa, M., Decaestecker, C., Remmelink, M., Sirtaine, N., Ernoux-Neufcoeur, P., Mutijima, E., Somja, J., Depuydt, C. E., Delvenne, P., Saussez, S."High incidence of high-risk HPV in benign and malignant lesions of the larynx". International Journal of Oncology 39, no. 1 (2011): 51-59. https://doi.org/10.3892/ijo.2011.1031
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