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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 2011 Volume 39 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2011 Volume 39 Issue 2

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Article

Promoter methylation of leukemia inhibitory factor receptor gene in colorectal carcinoma

  • Authors:
    • Yong Gu Cho
    • Xiaofei Chang
    • Il-Seok Park
    • Keishi Yamashita
    • Chunbo  Shao
    • Patrick K. Ha
    • Sara I. Pai
    • David Sidransky
    • Myoung Sook Kim

  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, Head and Neck Surgery, The Johns Hopkins University, 1550 Orleans Street, CRBII (Rm 574), Baltimore, MD 21231, USA
  • Pages: 337-344
    |
    Published online on: May 23, 2011
       https://doi.org/10.3892/ijo.2011.1050
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Abstract

Aberrant methylation of gene promoters and corresponding loss of gene expression plays a critical role in the initiation and progression of colorectal cancer. An IL-6-type cytokine receptor, leukemia inhibitory factor receptor (LIFR), is a component of cell-surface receptor complexes for multifunctional cytokines such as LIF. Herein, we report that LIFR is methylated in human colon cancer. LIFR promoter was methylated in primary tumor tissues with high frequency (65%, 52/80). Quantitative methylation-specific PCR (TaqMan-MSP) demonstrated differential promoter methylation of LIFR in primary colorectal cancer tissues as compared to normal colon tissues (5%, 4/80). LIFR methylation was not detectable in 13 normal colon mucosa samples obtained from patients without cancer. The mRNA expression of LIFR was significantly down-regulated in colon cancer tissues as compared to corresponding normal tissues. A strong expression of LIFR protein was observed in all non-malignant normal and adjacent normal colon mucosa tissues whereas down-regulated LIFR protein expression was observed in primary tumors. These results demonstrate that cancer-specific methylation and a specific decrease of LIFR expression are a common inactivation event in colon cancer development.

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Copy and paste a formatted citation
Spandidos Publications style
Cho YG, Chang X, Park I, Yamashita K, Shao C, Ha PK, Pai SI, Sidransky D and Kim MS: Promoter methylation of leukemia inhibitory factor receptor gene in colorectal carcinoma. Int J Oncol 39: 337-344, 2011.
APA
Cho, Y.G., Chang, X., Park, I., Yamashita, K., Shao, C., Ha, P.K. ... Kim, M.S. (2011). Promoter methylation of leukemia inhibitory factor receptor gene in colorectal carcinoma. International Journal of Oncology, 39, 337-344. https://doi.org/10.3892/ijo.2011.1050
MLA
Cho, Y. G., Chang, X., Park, I., Yamashita, K., Shao, C., Ha, P. K., Pai, S. I., Sidransky, D., Kim, M. S."Promoter methylation of leukemia inhibitory factor receptor gene in colorectal carcinoma". International Journal of Oncology 39.2 (2011): 337-344.
Chicago
Cho, Y. G., Chang, X., Park, I., Yamashita, K., Shao, C., Ha, P. K., Pai, S. I., Sidransky, D., Kim, M. S."Promoter methylation of leukemia inhibitory factor receptor gene in colorectal carcinoma". International Journal of Oncology 39, no. 2 (2011): 337-344. https://doi.org/10.3892/ijo.2011.1050
Copy and paste a formatted citation
x
Spandidos Publications style
Cho YG, Chang X, Park I, Yamashita K, Shao C, Ha PK, Pai SI, Sidransky D and Kim MS: Promoter methylation of leukemia inhibitory factor receptor gene in colorectal carcinoma. Int J Oncol 39: 337-344, 2011.
APA
Cho, Y.G., Chang, X., Park, I., Yamashita, K., Shao, C., Ha, P.K. ... Kim, M.S. (2011). Promoter methylation of leukemia inhibitory factor receptor gene in colorectal carcinoma. International Journal of Oncology, 39, 337-344. https://doi.org/10.3892/ijo.2011.1050
MLA
Cho, Y. G., Chang, X., Park, I., Yamashita, K., Shao, C., Ha, P. K., Pai, S. I., Sidransky, D., Kim, M. S."Promoter methylation of leukemia inhibitory factor receptor gene in colorectal carcinoma". International Journal of Oncology 39.2 (2011): 337-344.
Chicago
Cho, Y. G., Chang, X., Park, I., Yamashita, K., Shao, C., Ha, P. K., Pai, S. I., Sidransky, D., Kim, M. S."Promoter methylation of leukemia inhibitory factor receptor gene in colorectal carcinoma". International Journal of Oncology 39, no. 2 (2011): 337-344. https://doi.org/10.3892/ijo.2011.1050
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