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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 2011 Volume 39 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2011 Volume 39 Issue 4

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Article

Cisplatin and TRAIL enhance breast cancer stem cell death

  • Authors:
    • Shuping Yin
    • Liping Xu
    • Sudeshna Bandyopadhyay
    • Seema Sethi
    • Kaladhar B. Reddy

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Wayne State University School of Medicine, 540 E. Canfield, Detroit, MI 48201, USA, 540 E. Canfield Avenue, Department of Pathology, Wayne State University, Detroit, MI 48201, USA
  • Pages: 891-898
    |
    Published online on: June 16, 2011
       https://doi.org/10.3892/ijo.2011.1085
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Abstract

Triple negative breast cancer (TNBC) has increased recurrence and poor survival, despite a high response rate to neoadjuvant chemotherapy. The aim of this study was to determine whether current drug treatment(s) eliminates bulk of tumor cells, but it has a minimal effect on cancer stem cells (CSCs) leading to tumor recurrence. We studied the effects of PARP inhibitors (AZD2281 and BSI-201), paclitaxel, docetaxel, cisplatin and cisplatin plus TRAIL on CSCs derived from CRL-2335 and MDA-MB-468 TNBC cells in vitro. The in vitro data indicate that cisplatin plus TRIAL treatment was most effective in eliminating CSCs compared to PARP inhibitors, cisplatin, paclitaxel and docetaxel. Treatment with cisplatin plus TRAIL also inhibits Wnt-1 signaling and its downstream target, β-catenin, phospho β-catenin, cyclin D1, increased apoptosis, reduced proliferation and mammosphere formation. Inhibition of Wnt-1 by siRNA significantly reduced the ability of CSCs to form mammospheres compared to control. However, maximum effect was seen in cisplatin plus TRAIL-treated cells. Taken together the data suggest that cisplatin plus TRAIL treatment has the potential of providing a new strategy for improving the therapeutic outcome in TNBC patients.

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Copy and paste a formatted citation
Spandidos Publications style
Yin S, Xu L, Bandyopadhyay S, Sethi S and Reddy KB: Cisplatin and TRAIL enhance breast cancer stem cell death . Int J Oncol 39: 891-898, 2011.
APA
Yin, S., Xu, L., Bandyopadhyay, S., Sethi, S., & Reddy, K.B. (2011). Cisplatin and TRAIL enhance breast cancer stem cell death . International Journal of Oncology, 39, 891-898. https://doi.org/10.3892/ijo.2011.1085
MLA
Yin, S., Xu, L., Bandyopadhyay, S., Sethi, S., Reddy, K. B."Cisplatin and TRAIL enhance breast cancer stem cell death ". International Journal of Oncology 39.4 (2011): 891-898.
Chicago
Yin, S., Xu, L., Bandyopadhyay, S., Sethi, S., Reddy, K. B."Cisplatin and TRAIL enhance breast cancer stem cell death ". International Journal of Oncology 39, no. 4 (2011): 891-898. https://doi.org/10.3892/ijo.2011.1085
Copy and paste a formatted citation
x
Spandidos Publications style
Yin S, Xu L, Bandyopadhyay S, Sethi S and Reddy KB: Cisplatin and TRAIL enhance breast cancer stem cell death . Int J Oncol 39: 891-898, 2011.
APA
Yin, S., Xu, L., Bandyopadhyay, S., Sethi, S., & Reddy, K.B. (2011). Cisplatin and TRAIL enhance breast cancer stem cell death . International Journal of Oncology, 39, 891-898. https://doi.org/10.3892/ijo.2011.1085
MLA
Yin, S., Xu, L., Bandyopadhyay, S., Sethi, S., Reddy, K. B."Cisplatin and TRAIL enhance breast cancer stem cell death ". International Journal of Oncology 39.4 (2011): 891-898.
Chicago
Yin, S., Xu, L., Bandyopadhyay, S., Sethi, S., Reddy, K. B."Cisplatin and TRAIL enhance breast cancer stem cell death ". International Journal of Oncology 39, no. 4 (2011): 891-898. https://doi.org/10.3892/ijo.2011.1085
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