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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2011 Volume 39 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article Open Access

Identification of novel molecular targets regulated by tumor suppressive miR-1/miR-133a in maxillary sinus squamous cell carcinoma

  • Authors:
    • Nijiro Nohata
    • Toyoyuki Hanazawa
    • Naoko Kikkawa
    • Daiju Sakurai
    • Keita  Sasaki
    • Takeshi Chiyomaru
    • Kazumori Kawakami
    • Hirofumi Yoshino
    • Hideki  Enokida
    • Masayuki Nakagawa
    • Yoshitaka Okamoto
    • Naohiko Seki
  • View Affiliations / Copyright

    Affiliations: Department of Functional Genomics, Chiba University Graduate School of Medicine, Chiba, Japan, Department of Functional Genomics, Chiba University Graduate School of Medicine, 1-8-1 Inohana Chuo-ku, Chiba 260-8670, Japan
  • Pages: 1099-1107
    |
    Published online on: June 23, 2011
       https://doi.org/10.3892/ijo.2011.1096
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Abstract

Based on our microRNA (miRNA) expression signature analysis of maxillary sinus squamous cell carcinoma (MSSCC), we found that miR-1 and miR-133a were significantly reduced in tumor tissues. Quantitative real-time RT-PCR revealed that the expression levels of miR-1 and miR-133a were significantly downregulated in clinical MSSCC tumor tissues compared with normal tissues. We focused on the functional significance of miR-1 and miR-133a in cancer cells and identification of the novel cancer networks regulated by these miRNAs in MSSCC. Restoration of downregulated miRNAs (miR-1 or miR-133a) in cancer cells revealed that both miRNAs significantly inhibited cancer cell proliferation and induced cell apoptosis. Molecular target identification of these miRNAs showed that transgelin 2 (TAGLN2) and purine nucleoside phosphorylase (PNP) were regulated by miR-1 and miR-133a. Both TAGLN2 and PNP mRNA expression levels were significantly upregulated in clinical MSSCC tumor tissues. Silencing studies of target genes demonstrated that both genes inhibited cancer cell proliferation. The identification of novel miR-1/miR-133a-regulated cancer pathways could provide new insights into potential molecular mechanisms of MSSCC oncogenesis.

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Copy and paste a formatted citation
Spandidos Publications style
Nohata N, Hanazawa T, Kikkawa N, Sakurai D, Sasaki K, Chiyomaru T, Kawakami K, Yoshino H, Enokida H, Nakagawa M, Nakagawa M, et al: Identification of novel molecular targets regulated by tumor suppressive miR-1/miR-133a in maxillary sinus squamous cell carcinoma. Int J Oncol 39: 1099-1107, 2011.
APA
Nohata, N., Hanazawa, T., Kikkawa, N., Sakurai, D., Sasaki, K., Chiyomaru, T. ... Seki, N. (2011). Identification of novel molecular targets regulated by tumor suppressive miR-1/miR-133a in maxillary sinus squamous cell carcinoma. International Journal of Oncology, 39, 1099-1107. https://doi.org/10.3892/ijo.2011.1096
MLA
Nohata, N., Hanazawa, T., Kikkawa, N., Sakurai, D., Sasaki, K., Chiyomaru, T., Kawakami, K., Yoshino, H., Enokida, H., Nakagawa, M., Okamoto, Y., Seki, N."Identification of novel molecular targets regulated by tumor suppressive miR-1/miR-133a in maxillary sinus squamous cell carcinoma". International Journal of Oncology 39.5 (2011): 1099-1107.
Chicago
Nohata, N., Hanazawa, T., Kikkawa, N., Sakurai, D., Sasaki, K., Chiyomaru, T., Kawakami, K., Yoshino, H., Enokida, H., Nakagawa, M., Okamoto, Y., Seki, N."Identification of novel molecular targets regulated by tumor suppressive miR-1/miR-133a in maxillary sinus squamous cell carcinoma". International Journal of Oncology 39, no. 5 (2011): 1099-1107. https://doi.org/10.3892/ijo.2011.1096
Copy and paste a formatted citation
x
Spandidos Publications style
Nohata N, Hanazawa T, Kikkawa N, Sakurai D, Sasaki K, Chiyomaru T, Kawakami K, Yoshino H, Enokida H, Nakagawa M, Nakagawa M, et al: Identification of novel molecular targets regulated by tumor suppressive miR-1/miR-133a in maxillary sinus squamous cell carcinoma. Int J Oncol 39: 1099-1107, 2011.
APA
Nohata, N., Hanazawa, T., Kikkawa, N., Sakurai, D., Sasaki, K., Chiyomaru, T. ... Seki, N. (2011). Identification of novel molecular targets regulated by tumor suppressive miR-1/miR-133a in maxillary sinus squamous cell carcinoma. International Journal of Oncology, 39, 1099-1107. https://doi.org/10.3892/ijo.2011.1096
MLA
Nohata, N., Hanazawa, T., Kikkawa, N., Sakurai, D., Sasaki, K., Chiyomaru, T., Kawakami, K., Yoshino, H., Enokida, H., Nakagawa, M., Okamoto, Y., Seki, N."Identification of novel molecular targets regulated by tumor suppressive miR-1/miR-133a in maxillary sinus squamous cell carcinoma". International Journal of Oncology 39.5 (2011): 1099-1107.
Chicago
Nohata, N., Hanazawa, T., Kikkawa, N., Sakurai, D., Sasaki, K., Chiyomaru, T., Kawakami, K., Yoshino, H., Enokida, H., Nakagawa, M., Okamoto, Y., Seki, N."Identification of novel molecular targets regulated by tumor suppressive miR-1/miR-133a in maxillary sinus squamous cell carcinoma". International Journal of Oncology 39, no. 5 (2011): 1099-1107. https://doi.org/10.3892/ijo.2011.1096
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